Entity Details

Primary name DDX41_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UJV9
EntryNameDDX41_HUMAN
FullNameProbable ATP-dependent RNA helicase DDX41
TaxID9606
Evidenceevidence at protein level
Length622
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesDDX41

GO terms

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GOName
GO:0000398 mRNA splicing, via spliceosome
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0008283 cell population proliferation
GO:0016020 membrane
GO:0030154 cell differentiation
GO:0032481 positive regulation of type I interferon production
GO:0046872 metal ion binding
GO:0071013 catalytic step 2 spliceosome

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014014 RNA helicase, DEAD-box type, Q motifDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR044113 DDX41, DEAD-box helicase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616871 OMIMMyeloproliferative/lymphoproliferative neoplasms, familial (MPLPF)A familial cancer predisposition syndrome with incomplete penetrance, characterized by increased susceptibility to myeloid neoplasms and rarely to lymphoid malignancies. MPLPF inheritance is autosomal dominant. Disease susceptibility is associated with variants affecting the gene represented in this entry.