Entity Details

Primary name PEX16_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5Y5
EntryNamePEX16_HUMAN
FullNamePeroxisomal membrane protein PEX16
TaxID9606
Evidenceevidence at protein level
Length336
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesPEX16

GO terms

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GOName
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006625 protein targeting to peroxisome
GO:0007031 peroxisome organization
GO:0008022 protein C-terminus binding
GO:0016020 membrane
GO:0016557 peroxisome membrane biogenesis
GO:0016558 protein import into peroxisome matrix
GO:0022615 protein to membrane docking
GO:0032581 ER-dependent peroxisome organization
GO:0045046 protein import into peroxisome membrane
GO:0106101 ER-dependent peroxisome localization

Subcellular Location

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Subcellular Location
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR013919 Peroxisome membrane protein, Pex16FamilyFamily

Diseases

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Disease IDSourceNameDescription
614877 OMIMPeroxisome biogenesis disorder 8B (PBD8B)A relatively mild peroxisome biogenesis disorder. Affected individuals manifest lower limb spasticity and ataxia resulting in wheelchair dependence. Other features include optic atrophy, cataracts, dysarthria, dysphagia, constipation, and a peripheral demyelinating motor and sensory neuropathy. Cognition is relatively preserved. Biochemical abnormalities are mild and include increased very-long-chain fatty acids (VLCFA), increased bile acid intermediates, and increased branched chain fatty acids. Phytanic acid alpha-oxidation, pristanic acid beta-oxidation, and red cell plasmalogen are normal. The disease is caused by variants affecting the gene represented in this entry.
614876 OMIMPeroxisome biogenesis disorder complementation group 9 (PBD-CG9)A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). The disease is caused by variants affecting the gene represented in this entry.
614876 OMIMPeroxisome biogenesis disorder complementation group 9 (PBD-CG9)A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). The disease is caused by variants affecting the gene represented in this entry.

Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
PEX16_HUMANPEX19_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10704444 11390669 12096124 14709540 20531392 25416956 26186194 26264872 28514442 29997244 31467278 32814053 details
PEX16_HUMANPEX3_HUMANBioGRID, IntAct16280322 32296183 34079125 details
PEX16_HUMANCR3L1_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANVMAT1_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANSOAT_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANREEP4_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANPDZ1I_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANNTCP_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANTNR17_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANKCNJ6_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANRCAS1_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANLERL1_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANMF14B_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANTMX2_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANPGRC2_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANZDH15_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANGP152_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANEMC5_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANDEXI_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANCLC10_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANFFAR2_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
PEX16_HUMANBKRB2_HUMANBioGRID, MINT28298427 details
PEX16_HUMANOPTN_HUMANIntAct32814053 details
PEX16_HUMANFCERG_HUMANBioGRID32296183 details