Entity Details

Primary name PEX14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75381
EntryNamePEX14_HUMAN
FullNamePeroxisomal membrane protein PEX14
TaxID9606
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPEX14

GO terms

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GOName
GO:0001650 fibrillar center
GO:0003714 transcription corepressor activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0007031 peroxisome organization
GO:0008017 microtubule binding
GO:0008104 protein localization
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016558 protein import into peroxisome matrix
GO:0016560 protein import into peroxisome matrix, docking
GO:0016561 protein import into peroxisome matrix, translocation
GO:0016567 protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032991 protein-containing complex
GO:0034453 microtubule anchoring
GO:0036250 peroxisome transport along microtubule
GO:0042802 identical protein binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0044721 protein import into peroxisome matrix, substrate release
GO:0045046 protein import into peroxisome membrane
GO:0045892 negative regulation of transcription, DNA-templated
GO:0047485 protein N-terminus binding
GO:0048487 beta-tubulin binding
GO:0065003 protein-containing complex assembly
GO:1990429 peroxisomal importomer complex

Subcellular Location

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Subcellular Location
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR006785 Peroxisome membrane anchor protein Pex14p, N-terminalDomainDomain
IPR025655 Peroxisomal membrane protein 14FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614887 OMIMPeroxisome biogenesis disorder complementation group K (PBD-CGK)A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). The disease is caused by variants affecting the gene represented in this entry.
614887 OMIMPeroxisome biogenesis disorder complementation group K (PBD-CGK)A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). The disease is caused by variants affecting the gene represented in this entry.

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
PEX14_HUMANPEX14_HUMANBioGRID, HPRD, MINT10212238 12096124 21525035 details
PEX14_HUMANPEX13_HUMANBioGRID, IntAct, MINT11865044 12096124 21525035 details
PEX14_HUMANPEX5_HUMANBioGRID, HPRD, IntAct, MINT10022913 10212238 10837480 11865044 12096124 19197237 21525035 22002062 30375424 30378028 34079125 details
PEX14_HUMANPEX19_HUMANBioGRID, HPRD, IntAct, MINT10704444 12096124 19197237 21525035 26264872 29997244 31467278 34079125 details
PEX14_HUMANSMRC2_HUMANBioGRID, HPRD, IntAct16169070 details
PEX14_HUMANMED8_HUMANBioGRID, HPRD, IntAct16169070 details
PEX14_HUMANZHX1_HUMANBioGRID, HPRD, IntAct16169070 details
PEX14_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
PEX14_HUMANGET3_HUMANBioGRID, IntAct32296183 details
PEX14_HUMANMARF1_HUMANBioGRID, IntAct32296183 details
PEX14_HUMANCSN4_HUMANBioGRID, IntAct32296183 details
PEX14_HUMANCENPK_HUMANBioGRID, IntAct32296183 details
PEX14_HUMANPEX7_HUMANBioGRID, HPRD10212238 details
PEX14_HUMANPEX26_HUMANBioGRID30366024 30375424 details
PEX14_HUMANOGT1_HUMANBioGRID32994395 details
PEX14_HUMANNFE2_HUMANHPRD11863372 details
PEX14_HUMANTRAP1_HUMANMINT19197237 details
PEX14_HUMANSCP2_HUMANBioGRID, MINT20531392 34079125 details
PEX14_HUMANLONP2_HUMANIntAct22002062 details
PEX14_HUMANACOX1_HUMANIntAct22002062 details
PEX14_HUMANCDC5L_HUMANIntAct31413325 details
PEX14_HUMANPEX12_HUMANBioGRID21525035 details
PEX14_HUMANTCPG_HUMANBioGRID21525035 details
PEX14_HUMANDC1I2_HUMANBioGRID21525035 details
PEX14_HUMANS27A2_HUMANBioGRID10198260 details
PEX14_HUMANHDAC1_HUMANHPRD11863372 details