Entity Details

Primary name CRYAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02489
EntryNameCRYAA_HUMAN
FullNameAlpha-crystallin A chain
TaxID9606
Evidenceevidence at protein level
Length173
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005212 structural constituent of eye lens
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007601 visual perception
GO:0032387 negative regulation of intracellular transport
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0046872 metal ion binding
GO:0050821 protein stabilization
GO:0050896 response to stimulus
GO:0051082 unfolded protein binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001436 Alpha crystallin/Small heat shock protein, animal typeFamilyFamily
IPR002068 Alpha crystallin/Hsp20 domainDomainDomain
IPR003090 Alpha-crystallin, N-terminalDomainDomain
IPR008978 HSP20-like chaperoneFamilyHomologous superfamily
IPR012274 Alpha-crystallin, subunit AFamilyFamily

Diseases

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Disease IDSourceNameDescription
604219 OMIMCataract 9, multiple types (CTRCT9)An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT9 includes nuclear, zonular central nuclear, anterior polar, cortical, embryonal, anterior subcapsular, fan-shaped, and total cataracts, among others. In some cases cataract is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye. The disease is caused by variants affecting the gene represented in this entry.

Interactions

22 interactions

InteractorPartnerSourcesPublicationsLink
CRYAA_HUMANCRBB2_HUMANBioGRID, HPRD, MINT, UniProt11700327 12601044 details
CRYAA_HUMANCRGC_HUMANBioGRID, HPRD, MINT, UniProt11700327 12601044 15322286 details
CRYAA_HUMANCRYAB_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11700327 12601044 16142923 16760894 17260942 18401461 18639655 19651604 22085609 22153508 22427585 23188086 25416956 25694240 25910212 26657544 28919577 32296183 details
CRYAA_HUMANHSPB1_HUMANBioGRID, HPRD, MINT, UniProt11700327 12601044 details
CRYAA_HUMANCRYAA_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11700327 12601044 17724207 18639655 19651604 22085609 22427585 25416956 32296183 details
CRYAA_HUMANSDCB1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CRYAA_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CRYAA_HUMANGORS2_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
CRYAA_HUMANSPG21_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CRYAA_HUMANCRBA4_HUMANIntAct31254514 details
CRYAA_HUMANEGFL8_HUMANIntAct32814053 details
CRYAA_HUMANCRYA2_HUMANBioGRID, HPRD11700327 12601044 17724207 18639655 22085609 22427585 25416956 32296183 details
CRYAA_HUMANCRGD_HUMANBioGRID12601044 22655036 details
CRYAA_HUMANHSPB2_HUMANBioGRID12601044 details
CRYAA_HUMANB2CL1_HUMANBioGRID, HPRD14752512 details
CRYAA_HUMANBAX_HUMANBioGRID14752512 details
CRYAA_HUMANCRBA1_HUMANBioGRID19401464 26657544 details
CRYAA_HUMANMIP_HUMANBioGRID, HPRD18004741 8910261 details
CRYAA_HUMANCISY_HUMANHPRD11377425 details
CRYAA_HUMANQOR_HUMANHPRD11672428 details
CRYAA_HUMANLALBA_HUMANHPRD9346914 details
CRYAA_HUMANALBU_HUMANHPRD9618718 details