Entity Details

Primary name APOB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04114
EntryNameAPOB_HUMAN
FullNameApolipoprotein B-100
TaxID9606
Evidenceevidence at protein level
Length4563
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesAPOB

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001701 in utero embryonic development
GO:0002224 toll-like receptor signaling pathway
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006642 triglyceride mobilization
GO:0006898 receptor-mediated endocytosis
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0009566 fertilization
GO:0009615 response to virus
GO:0009743 response to carbohydrate
GO:0009791 post-embryonic development
GO:0010008 endosome membrane
GO:0010269 response to selenium ion
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010886 positive regulation of cholesterol storage
GO:0019433 triglyceride catabolic process
GO:0030301 cholesterol transport
GO:0030317 flagellated sperm motility
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031904 endosome lumen
GO:0031983 vesicle lumen
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0033344 cholesterol efflux
GO:0034359 mature chylomicron
GO:0034360 chylomicron remnant
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034378 chylomicron assembly
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0034447 very-low-density lipoprotein particle clearance
GO:0035473 lipase binding
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042953 lipoprotein transport
GO:0043025 neuronal cell body
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045540 regulation of cholesterol biosynthetic process
GO:0048844 artery morphogenesis
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050900 leukocyte migration
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0070971 endoplasmic reticulum exit site
GO:0071356 cellular response to tumor necrosis factor
GO:0071379 cellular response to prostaglandin stimulus
GO:0071682 endocytic vesicle lumen
GO:0120020 cholesterol transfer activity

Subcellular Location

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Subcellular Location
Cytoplasm
Lipid droplet
Secreted

Domains

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DomainNameCategoryType
IPR001747 Lipid transport protein, N-terminalDomainDomain
IPR009454 Lipid transport, open beta-sheetDomainDomain
IPR011030 Lipovitellin-phosvitin complex, superhelical domainFamilyHomologous superfamily
IPR015255 Vitellinogen, open beta-sheetDomainDomain
IPR015816 Vitellinogen, beta-sheet N-terminalFamilyHomologous superfamily
IPR015819 Lipid transport protein, beta-sheet shellFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR022176 Apolipoprotein B100 C-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
615558 OMIMHypobetalipoproteinemia, familial, 1 (FHBL1)A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. The disease is caused by variants affecting the gene represented in this entry. Most cases of FHBL1 result from nonsense mutations in the APOB gene that lead to a premature stop codon, which generate prematurely truncated apo B protein products (PubMed:21981844).
144010 OMIMHypercholesterolemia, familial, 2 (FHCL2)A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL2 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
APOB_HUMANAKT2_HUMANBioGRID, IntAct21988832 details
APOB_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
APOB_HUMANPRDX4_HUMANBioGRID, IntAct21988832 details
APOB_HUMANARFG1_HUMANBioGRID, IntAct21988832 details
APOB_HUMANLDLR_HUMANHPRD, MINT12031600 24447298 details
APOB_HUMANMTP_HUMANBioGRID, HPRD, IntAct11358959 26224785 27487388 9915855 details
APOB_HUMANPGS1_HUMANBioGRID, HPRD12070165 details
APOB_HUMANLIPC_HUMANBioGRID, HPRD9685400 details
APOB_HUMANLRP6_HUMANBioGRID18948618 details
APOB_HUMANTREM2_HUMANBioGRID27477018 details
APOB_HUMANCD36_HUMANBioGRID25555908 details
APOB_HUMANHS90A_HUMANBioGRID, HPRD11333259 31273033 details
APOB_HUMANAUP1_HUMANBioGRID, IntAct26186194 28183703 28514442 details
APOB_HUMANTERA_HUMANBioGRID, IntAct18550891 19164805 28183703 details
APOB_HUMANAPOA1_HUMANBioGRID, HPRD, IntAct19164805 28183703 7592581 details
APOB_HUMANDERL1_HUMANBioGRID, IntAct19164805 22238364 details
APOB_HUMANBIP_HUMANBioGRID, HPRD, IntAct12397072 19164805 details
APOB_HUMANCALX_HUMANBioGRID, HPRD14498830 9765244 details
APOB_HUMANCALR_HUMANBioGRID, HPRD10513896 12397072 9694898 details
APOB_HUMANENPL_HUMANBioGRID, HPRD12397072 9694898 details
APOB_HUMANPDIA4_HUMANBioGRID, HPRD12397072 9694898 details
APOB_HUMANCALCR_HUMANBioGRID12397072 details
APOB_HUMANPPIB_HUMANBioGRID, HPRD12397072 details
APOB_HUMANS61A1_HUMANBioGRID9565615 details
APOB_HUMANSC61B_HUMANBioGRID, HPRD9565615 details
APOB_HUMANAPOB_HUMANBioGRID19164805 details
APOB_HUMANFAF2_HUMANBioGRID22238364 26186194 details
APOB_HUMANPLIN2_HUMANBioGRID22238364 details
APOB_HUMANTGO1_HUMANBioGRID27138255 details
APOB_HUMANMIA2_HUMANBioGRID27138255 details
APOB_HUMANHS71A_HUMANHPRD9252351 details
APOB_HUMANHS71B_HUMANHPRD9252351 details
APOB_HUMANLRP2_HUMANHPRD10330424 details
APOB_HUMANHSP7C_HUMANHPRD9694898 details
APOB_HUMANS61A2_HUMANHPRD9565615 details