Entity Details

Primary name TY3H_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07101
EntryNameTY3H_HUMAN
FullNameTyrosine 3-monooxygenase
TaxID9606
Evidenceevidence at protein level
Length528
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesTH

GO terms

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GOName
GO:0007507 heart development
GO:0005737 cytoplasm
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031667 response to nutrient levels
GO:0033076 isoquinoline alkaloid metabolic process
GO:0009651 response to salt stress
GO:0009887 animal organ morphogenesis
GO:0034617 tetrahydrobiopterin binding
GO:0035176 social behavior
GO:0042421 norepinephrine biosynthetic process
GO:0046684 response to pyrethroid
GO:0071363 cellular response to growth factor stimulus
GO:0007605 sensory perception of sound
GO:0021987 cerebral cortex development
GO:0043195 terminal bouton
GO:0001963 synaptic transmission, dopaminergic
GO:0007626 locomotory behavior
GO:0008198 ferrous iron binding
GO:0032355 response to estradiol
GO:0043473 pigmentation
GO:0045472 response to ether
GO:0042423 catecholamine biosynthetic process
GO:0051412 response to corticosterone
GO:0005739 mitochondrion
GO:0006631 fatty acid metabolic process
GO:0008021 synaptic vesicle
GO:0009416 response to light stimulus
GO:0019825 oxygen binding
GO:0030425 dendrite
GO:0035240 dopamine binding
GO:0042462 eye photoreceptor cell development
GO:0043434 response to peptide hormone
GO:0005634 nucleus
GO:0007613 memory
GO:0009414 response to water deprivation
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0032496 response to lipopolysaccharide
GO:0042745 circadian sleep/wake cycle
GO:0042755 eating behavior
GO:0005790 smooth endoplasmic reticulum
GO:0031410 cytoplasmic vesicle
GO:0001975 response to amphetamine
GO:0016597 amino acid binding
GO:0042136 neurotransmitter biosynthetic process
GO:0005829 cytosol
GO:0033162 melanosome membrane
GO:0035902 response to immobilization stress
GO:0042214 terpene metabolic process
GO:0051602 response to electrical stimulus
GO:0071312 cellular response to alkaloid
GO:0042418 epinephrine biosynthetic process
GO:0003007 heart morphogenesis
GO:0014823 response to activity
GO:0043204 perikaryon
GO:0048596 embryonic camera-type eye morphogenesis
GO:0010043 response to zinc ion
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0001666 response to hypoxia
GO:0048471 perinuclear region of cytoplasm
GO:0030424 axon
GO:0071287 cellular response to manganese ion
GO:0006585 dopamine biosynthetic process from tyrosine
GO:0035690 cellular response to drug
GO:1990384 hyaloid vascular plexus regression
GO:0007612 learning
GO:0008199 ferric iron binding
GO:0009635 response to herbicide
GO:0018963 phthalate metabolic process
GO:0035900 response to isolation stress
GO:0045471 response to ethanol
GO:0071333 cellular response to glucose stimulus
GO:0006665 sphingolipid metabolic process
GO:0007617 mating behavior
GO:0016137 glycoside metabolic process
GO:0052314 phytoalexin metabolic process
GO:0004511 tyrosine 3-monooxygenase activity
GO:0007601 visual perception
GO:0009653 anatomical structure morphogenesis
GO:0042416 dopamine biosynthetic process
GO:0071316 cellular response to nicotine
GO:0008016 regulation of heart contraction
GO:0009898 cytoplasmic side of plasma membrane
GO:0010259 multicellular organism aging

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001273 Aromatic amino acid hydroxylaseFamilyFamily
IPR005962 Tyrosine 3-monooxygenaseFamilyFamily
IPR018301 Aromatic amino acid hydroxylase, iron/copper binding siteSiteBinding site
IPR019773 Tyrosine 3-monooxygenase-likeFamilyFamily
IPR019774 Aromatic amino acid hydroxylase, C-terminalDomainDomain
IPR021164 Tyrosine hydroxylase, conserved siteSiteConserved site
IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036951 Aromatic amino acid hydroxylase superfamilyFamilyHomologous superfamily
IPR041903 Tyrosine 3-monooxygenase, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
605407 OMIMSegawa syndrome autosomal recessive (ARSEGS)A form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00120 PhenylalanineDrugbanksmall molecule
DB00135 TyrosineDrugbanksmall molecule
DB00360 SapropterinDrugbanksmall molecule
DB00765 MetyrosineDrugbanksmall molecule
DB03552 3-TyrosineDrugbanksmall molecule
DB04400 L-erythro-7,8-dihydrobiopterinDrugbanksmall molecule