Entity Details

Primary name LMNB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20700
EntryNameLMNB1_HUMAN
FullNameLamin-B1
TaxID9606
Evidenceevidence at protein level
Length586
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesLMNB1

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005638 lamin filament
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0031965 nuclear membrane
GO:0035722 interleukin-12-mediated signaling pathway
GO:0043274 phospholipase binding
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus inner membrane

Domains

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DomainNameCategoryType
IPR001322 Lamin tail domainDomainDomain
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR036415 Lamin tail domain superfamilyFamilyHomologous superfamily
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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Disease IDSourceNameDescription
169500 OMIMLeukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD)A slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis. The disease is caused by variants affecting the gene represented in this entry.

Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
LMNB1_HUMANPASK_HUMANMINT21418524 details
LMNB1_HUMANPIAS2_HUMANBioGRID, MINT21516116 34079125 details
LMNB1_HUMANAACT_HUMANBioGRID, IntAct21988832 details
LMNB1_HUMANATF4_HUMANBioGRID, IntAct21988832 details
LMNB1_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
LMNB1_HUMANMBIP1_HUMANBioGRID, IntAct21988832 details
LMNB1_HUMANABCG8_HUMANBioGRID, IntAct21988832 details
LMNB1_HUMANLMNA_HUMANBioGRID, DIP, HPRD, IntAct11792809 19727227 21346760 21988832 22412018 24623722 25948554 26264872 26524528 29568061 29997244 30021884 30419336 31467278 32814053 34079125 details
LMNB1_HUMANLMNB1_HUMANMINT22265972 details
LMNB1_HUMANLAP2B_HUMANBioGRID, IntAct26496610 34079125 8324822 9490046 details
LMNB1_HUMANIMA5_HUMANBioGRID, IntAct26496610 32296183 34079125 details
LMNB1_HUMANLMNB2_HUMANBioGRID, DIP, IntAct24981860 26524528 30021884 32296183 34079125 details
LMNB1_HUMANM1AP_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANSNAPN_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANDMAP1_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANASPP1_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANCC88B_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANCENPH_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANF169A_HUMANBioGRID, IntAct32296183 34079125 details
LMNB1_HUMANIMA7_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANPIHD2_HUMANBioGRID, IntAct32296183 details
LMNB1_HUMANMLP3B_HUMANBioGRID, DIP26524528 details
LMNB1_HUMANMLP3C_HUMANBioGRID, DIP26524528 details
LMNB1_HUMANMLP3A_HUMANBioGRID, DIP26524528 details
LMNB1_HUMANGBRAP_HUMANBioGRID, DIP26524528 details
LMNB1_HUMANKPCB_HUMANBioGRID, HPRD11901153 8034666 details
LMNB1_HUMANKPCA_HUMANBioGRID, HPRD11901153 12135703 details
LMNB1_HUMANLAP2A_HUMANBioGRID, HPRD26496610 34079125 8324822 9490046 details
LMNB1_HUMANCDK1_HUMANBioGRID, HPRD11901153 8034666 details
LMNB1_HUMANMELK_HUMANBioGRID, HPRD16216881 details
LMNB1_HUMANURB2_HUMANBioGRID, HPRD15265697 details
LMNB1_HUMAN1433T_HUMANBioGRID15161933 details
LMNB1_HUMANSRPK2_HUMANBioGRID26167880 details
LMNB1_HUMANAKTIP_HUMANBioGRID27512140 details
LMNB1_HUMANRN123_HUMANBioGRID29676528 details
LMNB1_HUMANUBC9_HUMANBioGRID32296183 details
LMNB1_HUMANASPP2_HUMANBioGRID32296183 details
LMNB1_HUMANIMA6_HUMANBioGRID32296183 details
LMNB1_HUMANPTEN_HUMANBioGRID31685992 details
LMNB1_HUMANRTCA_HUMANIntAct17353931 details
LMNB1_HUMANBCAR3_HUMANIntAct17353931 details
LMNB1_HUMANATG12_HUMANIntAct17353931 details
LMNB1_HUMANHLAB_HUMANIntAct17353931 details
LMNB1_HUMAN1433Z_HUMANMINT15161933 details
LMNB1_HUMANAIRE_HUMANBioGRID, IntAct20085707 details
LMNB1_HUMANSEP12_HUMANIntAct25775403 details
LMNB1_HUMANEMD_HUMANBioGRID12670476 17620012 34079125 details
LMNB1_HUMANVIME_HUMANBioGRID11441066 details
LMNB1_HUMANSPTN1_HUMANBioGRID11441066 details
LMNB1_HUMANNDEL1_HUMANBioGRID19198602 details
LMNB1_HUMANSMCA4_HUMANBioGRID9128241 details
LMNB1_HUMANPO2F1_HUMANBioGRID21897860 23580612 details
LMNB1_HUMANSMRCD_HUMANBioGRID21549307 details
LMNB1_HUMANRNF13_HUMANBioGRID20230530 details
LMNB1_HUMANPCGF2_HUMANBioGRID19727227 details
LMNB1_HUMANEGF_HUMANBioGRID19727227 details
LMNB1_HUMANHECW2_HUMANBioGRID24163370 29753763 details
LMNB1_HUMANSPRTN_HUMANBioGRID23254330 details
LMNB1_HUMANRAC1_HUMANBioGRID19961560 details
LMNB1_HUMANABCE1_HUMANBioGRID25659154 details
LMNB1_HUMANCTNB1_HUMANBioGRID26912724 27684187 details
LMNB1_HUMANRAD51_HUMANBioGRID28613254 details
LMNB1_HUMANST7_HUMANBioGRID29395067 details
LMNB1_HUMANEIF3H_HUMANBioGRID32269044 details
LMNB1_HUMANLBR_HUMANBioGRID, HPRD12490158 34079125 details
LMNB1_HUMANTOIP1_HUMANBioGRID, HPRD34079125 9305626 details
LMNB1_HUMANSUMO4_HUMANHPRD16236267 details
LMNB1_HUMANGRAB_HUMANHPRD11331782 details
LMNB1_HUMANGRAA_HUMANHPRD11331782 details
LMNB1_HUMANPERI_HUMANHPRD1986862 details
LMNB1_HUMANKPCD_HUMANHPRD11901153 details
LMNB1_HUMANCASP3_HUMANHPRD11901153 details
LMNB1_HUMANPLEC_HUMANHPRD2023931 details
LMNB1_HUMANCASP6_HUMANHPRD11331782 11901153 details