Entity Details

Primary name SCP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22307
EntryNameSCP2_HUMAN
FullNameSterol carrier protein 2
TaxID9606
Evidenceevidence at protein level
Length547
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesSCP2

GO terms

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GOName
GO:0000062 fatty-acyl-CoA binding
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0005102 signaling receptor binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006635 fatty acid beta-oxidation
GO:0006694 steroid biosynthetic process
GO:0006699 bile acid biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0007031 peroxisome organization
GO:0008104 protein localization
GO:0008206 bile acid metabolic process
GO:0008526 phosphatidylinositol transfer activity
GO:0015485 cholesterol binding
GO:0015914 phospholipid transport
GO:0016020 membrane
GO:0032367 intracellular cholesterol transport
GO:0032385 positive regulation of intracellular cholesterol transport
GO:0032934 sterol binding
GO:0032959 inositol trisphosphate biosynthetic process
GO:0032991 protein-containing complex
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033814 propanoyl-CoA C-acyltransferase activity
GO:0036042 long-chain fatty acyl-CoA binding
GO:0036109 alpha-linolenic acid metabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045940 positive regulation of steroid metabolic process
GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity
GO:0050633 acetyl-CoA C-myristoyltransferase activity
GO:0070538 oleic acid binding
GO:0071071 regulation of phospholipid biosynthetic process
GO:0072659 protein localization to plasma membrane
GO:0120019 phosphatidylcholine transfer activity
GO:0120020 cholesterol transfer activity
GO:1901373 lipid hydroperoxide transport

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Mitochondrion
Peroxisome

Domains

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DomainNameCategoryType
IPR003033 SCP2 sterol-binding domainDomainDomain
IPR016039 Thiolase-likeFamilyHomologous superfamily
IPR020613 Thiolase, conserved siteSiteConserved site
IPR020615 Thiolase, acyl-enzyme intermediate active siteSiteActive site
IPR020616 Thiolase, N-terminalDomainDomain
IPR020617 Thiolase, C-terminalDomainDomain
IPR036527 SCP2 sterol-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613724 OMIMLeukoencephalopathy with dystonia and motor neuropathy (LKDMN)A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. The disease is caused by variants affecting the gene represented in this entry.