Entity Details

Primary name TNFL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23510
EntryNameTNFL4_HUMAN
FullNameTumor necrosis factor ligand superfamily member 4
TaxID9606
Evidenceevidence at protein level
Length183
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesTNFSF4

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0002215 defense response to nematode
GO:0002526 acute inflammatory response
GO:0002639 positive regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0002819 regulation of adaptive immune response
GO:0002830 positive regulation of type 2 immune response
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0009986 cell surface
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035709 memory T cell activation
GO:0035712 T-helper 2 cell activation
GO:0035713 response to nitrogen dioxide
GO:0042102 positive regulation of T cell proliferation
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043382 positive regulation of memory T cell differentiation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050871 positive regulation of B cell activation
GO:0071222 cellular response to lipopolysaccharide
GO:0071380 cellular response to prostaglandin E stimulus
GO:1900281 positive regulation of CD4-positive, alpha-beta T cell costimulation
GO:2000572 positive regulation of interleukin-4-dependent isotype switching to IgE isotypes

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR006052 Tumour necrosis factor domainDomainDomain
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site
IPR042338 Tumor necrosis factor ligand superfamily member 4FamilyFamily

Diseases

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Disease IDSourceNameDescription
152700 OMIMSystemic lupus erythematosus (SLE)A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variants affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TNFL4_HUMANTNR4_HUMANDIP, HPRD12134113 16905106 details
TNFL4_HUMANTRAF2_HUMANHPRD9418902 details