Entity Details

Primary name AMRP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30533
EntryNameAMRP_HUMAN
FullNameAlpha-2-macroglobulin receptor-associated protein
TaxID9606
Evidenceevidence at protein level
Length357
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesLRPAP1

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002091 negative regulation of receptor internalization
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005801 cis-Golgi network
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0008201 heparin binding
GO:0009986 cell surface
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0012505 endomembrane system
GO:0031904 endosome lumen
GO:0032091 negative regulation of protein binding
GO:0035473 lipase binding
GO:0048018 receptor ligand activity
GO:0048019 receptor antagonist activity
GO:0048237 rough endoplasmic reticulum lumen
GO:0048259 regulation of receptor-mediated endocytosis
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060548 negative regulation of cell death
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0150093 amyloid-beta clearance by transcytosis
GO:1900116 extracellular negative regulation of signal transduction
GO:1900222 negative regulation of amyloid-beta clearance
GO:1900223 positive regulation of amyloid-beta clearance

Subcellular Location

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Subcellular Location
Cell surface
Endoplasmic reticulum-Golgi intermediate compartment lumen
Endosome lumen
Golgi apparatus
Golgi apparatus lumen
Rough endoplasmic reticulum lumen

Domains

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DomainNameCategoryType
IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1DomainDomain
IPR010483 Alpha-2-macroglobulin RAP, C-terminalDomainDomain
IPR036744 RAP domain superfamilyFamilyHomologous superfamily
IPR037999 Alpha-2-macroglobulin RAP, domain 3DomainDomain
IPR038001 Alpha-2-macroglobulin RAP, domain 2DomainDomain
IPR038003 Alpha-2-macroglobulin receptor-associated proteinFamilyFamily

Diseases

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Disease IDSourceNameDescription
615431 OMIMMyopia 23, autosomal recessive (MYP23)A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. The disease is caused by variants affecting the gene represented in this entry.

Interactions

23 interactions

InteractorPartnerSourcesPublicationsLink
AMRP_HUMANDPOA2_HUMANBioGRID, HPRD, IntAct16169070 details
AMRP_HUMANRTN4_HUMANBioGRID, HPRD, IntAct16169070 details
AMRP_HUMANPPM1G_HUMANHPRD, IntAct16169070 details
AMRP_HUMANRBP2_HUMANBioGRID, IntAct20936779 details
AMRP_HUMANETV7_HUMANBioGRID, IntAct21988832 details
AMRP_HUMANSORT_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct10085125 18687776 19122660 20584990 9013611 9927419 details
AMRP_HUMANVLDLR_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct10571241 12899622 20223215 28514442 7592875 8083232 details
AMRP_HUMANSORL_HUMANbhf-ucl, BioGRID, HPRD, IntAct11294867 11557679 17326667 26858303 28514442 8940146 details
AMRP_HUMANLRP1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, UniProt10747918 1374383 16101684 1718973 17326667 20030366 28514442 details
AMRP_HUMANASPH_HUMANBioGRID, IntAct32296183 details
AMRP_HUMANLRP8_HUMANBioGRID, DIP, HPRD, IntAct10231386 12899622 16101684 20223215 28514442 details
AMRP_HUMANLRP2_HUMANBioGRID, HPRD, IntAct11912251 16101684 28514442 7512726 details
AMRP_HUMANLDLR_HUMANBioGRID, HPRD, IntAct, UniProt20030366 28514442 7822276 details
AMRP_HUMANA4_HUMANIntAct32814053 details
AMRP_HUMANRAF1_HUMANBioGRID10783161 details
AMRP_HUMANGNDS_HUMANBioGRID10783161 details
AMRP_HUMANSMAD2_HUMANIntAct20195357 details
AMRP_HUMANLRP1B_HUMANBioGRID, HPRD, IntAct11384978 28514442 details
AMRP_HUMAN4EBP1_HUMANBioGRID16798736 details
AMRP_HUMANMTOR_HUMANBioGRID16798736 details
AMRP_HUMANP53_HUMANBioGRID15489903 details
AMRP_HUMANMK03_HUMANHPRD15342917 details
AMRP_HUMANMK01_HUMANHPRD15342917 details