Entity Details

Primary name MYH9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35579
EntryNameMYH9_HUMAN
FullNameMyosin-9
TaxID9606
Evidenceevidence at protein level
Length1960
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesMYH9

GO terms

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GOName
GO:0000146 microfilament motor activity
GO:0000212 meiotic spindle organization
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0001768 establishment of T cell polarity
GO:0001772 immunological synapse
GO:0001778 plasma membrane repair
GO:0001931 uropod
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003723 RNA binding
GO:0003774 cytoskeletal motor activity
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005826 actomyosin contractile ring
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0006509 membrane protein ectodomain proteolysis
GO:0006911 phagocytosis, engulfment
GO:0007229 integrin-mediated signaling pathway
GO:0007520 myoblast fusion
GO:0008360 regulation of cell shape
GO:0009898 cytoplasmic side of plasma membrane
GO:0015031 protein transport
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016460 myosin II complex
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0030048 actin filament-based movement
GO:0030220 platelet formation
GO:0030224 monocyte differentiation
GO:0031032 actomyosin structure organization
GO:0031252 cell leading edge
GO:0031532 actin cytoskeleton reorganization
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0032418 lysosome localization
GO:0032506 cytokinetic process
GO:0032796 uropod organization
GO:0032991 protein-containing complex
GO:0042641 actomyosin
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043495 protein-membrane adaptor activity
GO:0043531 ADP binding
GO:0043534 blood vessel endothelial cell migration
GO:0045055 regulated exocytosis
GO:0045296 cadherin binding
GO:0050900 leukocyte migration
GO:0051015 actin filament binding
GO:0051295 establishment of meiotic spindle localization
GO:0060471 cortical granule exocytosis
GO:0060473 cortical granule
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0097513 myosin II filament
GO:1903919 negative regulation of actin filament severing
GO:1903923 positive regulation of protein processing in phagocytic vesicle
GO:1905684 regulation of plasma membrane repair

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR001609 Myosin head, motor domainDomainDomain
IPR002928 Myosin tailDomainDomain
IPR004009 Myosin, N-terminal, SH3-likeDomainDomain
IPR008989 Myosin S1 fragment, N-terminalFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
603622 OMIMDeafness, autosomal dominant, 17 (DFNA17)A form of deafness characterized by progressive high frequency hearing impairment and cochleosaccular degeneration. The disease is caused by variants affecting the gene represented in this entry.
155100 OMIMMacrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss (MATINS)An autosomal dominant disorder characterized by thrombocytopenia, giant platelets and Dohle body-like inclusions in peripheral blood leukocytes with variable ultrastructural appearance. Some affected individuals lack leukocyte inclusion bodies on classic staining of peripheral blood smears. Alport syndrome-like features of nephritis, hearing loss, and eye abnormalities are present in some patients. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11638 ArtenimolDrugbanksmall molecule

Interactions

84 interactions

InteractorPartnerSourcesPublicationsLink
MYH9_HUMANGRB2_HUMANBioGRID, IntAct12577067 20936779 24189400 details
MYH9_HUMANASCC2_HUMANBioGRID, HPRD, IntAct16169070 details
MYH9_HUMANMYL9_HUMANBioGRID, HPRD, IntAct16169070 22863883 details
MYH9_HUMANS100P_HUMANIntAct, UniProt15171681 31837246 details
MYH9_HUMANMEN1_HUMANBioGRID, HPRD, IntAct14508515 details
MYH9_HUMANTRPM7_HUMANMINT18675813 details
MYH9_HUMANTRPM6_HUMANMINT18675813 details
MYH9_HUMAN1433Z_HUMANBioGRID, MINT20618440 20936779 details
MYH9_HUMANRAC1_HUMANBioGRID, IntAct20936779 details
MYH9_HUMANCASP4_HUMANBioGRID, IntAct21988832 details
MYH9_HUMANPP2AA_HUMANBioGRID, IntAct21988832 details
MYH9_HUMANMYH10_HUMANBioGRID, HPRD, IntAct16596254 22939629 24981860 26496610 details
MYH9_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
MYH9_HUMANS10A4_HUMANDIP, HPRD, UniProt15289939 20421509 22460785 22483112 31837246 9405067 details
MYH9_HUMANMYH9_HUMANDIP, UniProt22483112 31837246 details
MYH9_HUMANS10A1_HUMANUniProt31837246 details
MYH9_HUMANS10A2_HUMANUniProt31837246 details
MYH9_HUMANS10A3_HUMANUniProt31837246 details
MYH9_HUMANS10A5_HUMANUniProt31837246 details
MYH9_HUMANS10A6_HUMANUniProt31837246 details
MYH9_HUMANS10A7_HUMANUniProt31837246 details
MYH9_HUMANS10AB_HUMANUniProt31837246 details
MYH9_HUMANS10AE_HUMANUniProt31837246 details
MYH9_HUMANS1A7A_HUMANUniProt31837246 details
MYH9_HUMANS100B_HUMANUniProt31837246 details
MYH9_HUMANS100G_HUMANUniProt31837246 details
MYH9_HUMANCBL_HUMANBioGRID19380743 21203488 details
MYH9_HUMANACE_HUMANBioGRID16186248 details
MYH9_HUMANCSK21_HUMANBioGRID16186248 details
MYH9_HUMANUBC9_HUMANBioGRID19596686 details
MYH9_HUMANIKKA_HUMANIntAct14743216 details
MYH9_HUMANIKKE_HUMANIntAct14743216 details
MYH9_HUMANNEMO_HUMANIntAct14743216 details
MYH9_HUMANM3K3_HUMANIntAct14743216 details
MYH9_HUMANRIPK2_HUMANIntAct14743216 details
MYH9_HUMANTNR1A_HUMANIntAct14743216 details
MYH9_HUMANTNR1B_HUMANIntAct14743216 details
MYH9_HUMANCXCR4_HUMANHPRD, IntAct12421915 details
MYH9_HUMANCCR5_HUMANIntAct12421915 details
MYH9_HUMANNUCL_HUMANIntAct16403913 details
MYH9_HUMANUBP45_HUMANBioGRID, IntAct19615732 25538220 details
MYH9_HUMANWNK1_HUMANIntAct20936779 details
MYH9_HUMANATG9A_HUMANBioGRID, MINT21169990 details
MYH9_HUMANFINC_HUMANBioGRID, IntAct19738201 23750785 details
MYH9_HUMANKPCD2_HUMANBioGRID, MINT22909819 30652415 details
MYH9_HUMANSVIL_HUMANBioGRID, HPRD, IntAct12202484 17925381 26496610 details
MYH9_HUMANACTB_HUMANBioGRID, IntAct16186248 22366308 26496610 details
MYH9_HUMANROCK1_HUMANDIP26368311 details
MYH9_HUMANFXR1_HUMANMINT21653829 details
MYH9_HUMANMARK4_HUMANBioGRID14594945 details
MYH9_HUMANKPCE_HUMANBioGRID11897493 details
MYH9_HUMANEMD_HUMANBioGRID17620012 details
MYH9_HUMANTERF1_HUMANBioGRID20811636 details
MYH9_HUMANTERF2_HUMANBioGRID20811636 details
MYH9_HUMANPTPA_HUMANBioGRID19156129 details
MYH9_HUMAN1433T_HUMANBioGRID20618440 details
MYH9_HUMANHDAC5_HUMANBioGRID21081666 details
MYH9_HUMANNCOA3_HUMANBioGRID16051665 details
MYH9_HUMANCBP_HUMANBioGRID16051665 details
MYH9_HUMANUBE3A_HUMANBioGRID16051665 details
MYH9_HUMANTRAF4_HUMANBioGRID16969126 details
MYH9_HUMANISG15_HUMANBioGRID16009940 33024031 details
MYH9_HUMANTRI72_HUMANBioGRID22253476 details
MYH9_HUMANTSG10_HUMANBioGRID20797700 details
MYH9_HUMANHS90A_HUMANBioGRID16263121 details
MYH9_HUMANPK3C3_HUMANBioGRID23569248 details
MYH9_HUMANBOP1_HUMANBioGRID25825154 details
MYH9_HUMANPESC_HUMANBioGRID25825154 details
MYH9_HUMANEGFR_HUMANBioGRID22366308 details
MYH9_HUMANCASL_HUMANBioGRID30267961 details
MYH9_HUMANAKT1_HUMANBioGRID24462114 details
MYH9_HUMANGSK3B_HUMANBioGRID30711629 31594754 31754475 details
MYH9_HUMANFOXO1_HUMANBioGRID31754475 details
MYH9_HUMANNREP_HUMANBioGRID25336651 details
MYH9_HUMANEPHA3_HUMANBioGRID31577226 details
MYH9_HUMANPTN6_HUMANHPRD12705885 details
MYH9_HUMANOVGP1_HUMANHPRD16567366 details
MYH9_HUMANTITIN_HUMANHPRD8063857 details
MYH9_HUMANMYPC3_HUMANHPRD10672519 352343 6448079 details
MYH9_HUMANEFTU_HUMANHPRD12577067 details
MYH9_HUMANMYOM1_HUMANHPRD7588733 details
MYH9_HUMANMYOM2_HUMANHPRD9529381 details
MYH9_HUMANC163A_HUMANHPRD15479433 details
MYH9_HUMANNMDZ1_HUMANHPRD10862698 details