Entity Details

Primary name GLRB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48167
EntryNameGLRB_HUMAN
FullNameGlycine receptor subunit beta
TaxID9606
Evidenceevidence at protein level
Length497
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGLRB

GO terms

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GOName
GO:0001964 startle response
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007340 acrosome reaction
GO:0007399 nervous system development
GO:0007601 visual perception
GO:0007628 adult walking behavior
GO:0016594 glycine binding
GO:0016933 extracellularly glycine-gated ion channel activity
GO:0016934 extracellularly glycine-gated chloride channel activity
GO:0016935 glycine-gated chloride channel complex
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0043200 response to amino acid
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050877 nervous system process
GO:0060012 synaptic transmission, glycinergic
GO:0060013 righting reflex
GO:0097112 gamma-aminobutyric acid receptor clustering
GO:0098690 glycinergic synapse
GO:0098982 GABA-ergic synapse
GO:1902476 chloride transmembrane transport
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR008060 Glycine receptor betaFamilyFamily
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614619 OMIMHyperekplexia 2 (HKPX2)A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00145 GlycineDrugbanksmall molecule
DB00431 LindaneDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB05885 SeletracetamDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GLRB_HUMANGEPH_HUMANBioGRID, HPRD7546736 details
GLRB_HUMANA4_HUMANBioGRID21244100 details
GLRB_HUMANEPHA4_HUMANIntAct31413325 details