Entity Details

Primary name LMAN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49257
EntryNameLMAN1_HUMAN
FullNameProtein ERGIC-53
TaxID9606
Evidenceevidence at protein level
Length510
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesLMAN1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005537 mannose binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0006457 protein folding
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0007596 blood coagulation
GO:0010638 positive regulation of organelle organization
GO:0012507 ER to Golgi transport vesicle membrane
GO:0015031 protein transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030017 sarcomere
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0046872 metal ion binding
GO:0048208 COPII vesicle coating
GO:0051082 unfolded protein binding
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:1903215 negative regulation of protein targeting to mitochondrion

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR005052 Legume-like lectinDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR033085 Protein ERGIC-53FamilyFamily

Diseases

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Disease IDSourceNameDescription
227300 OMIMFactor V and factor VIII combined deficiency 1 (F5F8D1)A blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
LMAN1_HUMANMCFD2_HUMANBioGRID, DIP, HPRD, IntAct, MINT12717434 16304051 17971482 19787799 20138881 20142513 details
LMAN1_HUMANBAP31_HUMANBioGRID19342655 34079125 details
LMAN1_HUMANA4_HUMANBioGRID21832049 details
LMAN1_HUMANOGT1_HUMANBioGRID32994395 details
LMAN1_HUMANSNX9_HUMANMINT15703209 details
LMAN1_HUMANVHL_HUMANIntAct17353931 details
LMAN1_HUMANERP44_HUMANMINT17805346 details
LMAN1_HUMANSURF4_HUMANUniProt18287528 details
LMAN1_HUMANPTN2_HUMANUniProt16595549 details
LMAN1_HUMANTMED5_HUMANMINT22094269 details
LMAN1_HUMANTECT2_HUMANBioGRID, IntAct26638075 27173435 unassigned1312 details
LMAN1_HUMANCLPT1_HUMANBioGRID, IntAct27173435 unassigned1312 details
LMAN1_HUMANCALX_HUMANBioGRID, IntAct19342655 26344197 29568061 details
LMAN1_HUMANFA8_HUMANBioGRID, HPRD14629470 details
LMAN1_HUMANBAP29_HUMANBioGRID19342655 details
LMAN1_HUMANHLAA_HUMANBioGRID19342655 34079125 details
LMAN1_HUMANUBXN6_HUMANBioGRID22337587 details
LMAN1_HUMANRBGPR_HUMANBioGRID22337587 details
LMAN1_HUMANRB3GP_HUMANBioGRID22337587 details
LMAN1_HUMANHSP7C_HUMANBioGRID22337587 33957083 details
LMAN1_HUMANHS71A_HUMANBioGRID22337587 details
LMAN1_HUMANHS71B_HUMANBioGRID22337587 details
LMAN1_HUMANCOPA_HUMANBioGRID22337587 34079125 details
LMAN1_HUMANTERA_HUMANBioGRID22337587 details
LMAN1_HUMANTBB3_HUMANBioGRID22337587 details
LMAN1_HUMANTBB4B_HUMANBioGRID22337587 details
LMAN1_HUMANCOPB2_HUMANBioGRID22337587 details
LMAN1_HUMANCOPE_HUMANBioGRID22337587 details
LMAN1_HUMANCOPB_HUMANBioGRID22337587 details
LMAN1_HUMANDNJC7_HUMANBioGRID22337587 34079125 details
LMAN1_HUMANPDIA1_HUMANBioGRID22337587 26344197 details
LMAN1_HUMANYIPF3_HUMANBioGRID21757827 details
LMAN1_HUMANA1AT_HUMANBioGRID31142615 details
LMAN1_HUMANST7_HUMANBioGRID29395067 details
LMAN1_HUMANISG15_HUMANBioGRID33024031 details