Entity Details

Primary name CY561_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49447
EntryNameCY561_HUMAN
FullNameTransmembrane ascorbate-dependent reductase CYB561
TaxID9606
Evidenceevidence at protein level
Length251
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCYB561

GO terms

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GOName
GO:0000293 ferric-chelate reductase activity
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0016491 oxidoreductase activity
GO:0022900 electron transport chain
GO:0042584 chromaffin granule membrane
GO:0046872 metal ion binding
GO:0140575 transmembrane monodehydroascorbate reductase activity
GO:0140576 ascorbate homeostasis

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR006593 Cytochrome b561/ferric reductase transmembraneDomainDomain
IPR028837 Transmembrane ascorbate-dependent reductase CYB561FamilyFamily
IPR043205 Cytochrome b561/Cytochrome b reductase 1-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
618182 OMIMOrthostatic hypotension 2 (ORTHYP2)An autosomal recessive disorder characterized by severe orthostatic hypotension apparent from infancy or early childhood, low plasma and urinary levels of norepinephrine and epinephrine, and episodic hypoglycemia. Some patients may also have renal dysfunction and reduced life expectancy. Orthostatic hypotension, also known as postural hypotension, is a finding defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure occurring 3 minutes after a person has risen from supine to standing. Symptoms include dizziness, blurred vision, and sometimes syncope. The disease is caused by variants affecting the gene represented in this entry.

Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
CY561_HUMANORML2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
CY561_HUMANGGT7_HUMANBioGRID, IntAct32296183 details
CY561_HUMANHMOX1_HUMANBioGRID, IntAct32296183 details
CY561_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTREX1_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTMPPE_HUMANBioGRID, IntAct32296183 details
CY561_HUMANEFNA5_HUMANBioGRID, IntAct32296183 details
CY561_HUMANUB2J1_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTMM65_HUMANBioGRID, IntAct32296183 details
CY561_HUMANANR46_HUMANBioGRID, IntAct32296183 details
CY561_HUMANBET1_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTM128_HUMANBioGRID, IntAct32296183 details
CY561_HUMANT179B_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSTX3_HUMANBioGRID, IntAct32296183 details
CY561_HUMANVAPB_HUMANBioGRID, IntAct32296183 details
CY561_HUMANREEP6_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSSMM1_HUMANBioGRID, IntAct32296183 details
CY561_HUMANS39A2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANGPX8_HUMANBioGRID, IntAct32296183 details
CY561_HUMANBIK_HUMANBioGRID, IntAct32296183 details
CY561_HUMANZDHC7_HUMANBioGRID, IntAct32296183 details
CY561_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
CY561_HUMANPLP2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSEC20_HUMANBioGRID, IntAct32296183 details
CY561_HUMANS19A3_HUMANBioGRID, IntAct32296183 details
CY561_HUMANCREB3_HUMANBioGRID, MINT21516116 details
CY561_HUMANFKBP8_HUMANBioGRID, IntAct32296183 details
CY561_HUMANS39A1_HUMANBioGRID, IntAct32296183 details
CY561_HUMANLMNA_HUMANBioGRID24623722 details
CY561_HUMANEBP_HUMANBioGRID, IntAct32296183 details
CY561_HUMANVAPA_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTM242_HUMANBioGRID, IntAct32296183 details
CY561_HUMANEDA_HUMANBioGRID, IntAct25416956 32296183 details
CY561_HUMANT4S18_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSERP2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSCD_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSYJ2B_HUMANBioGRID, IntAct32296183 details
CY561_HUMANCKLF2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANCLD9_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSYDM_HUMANBioGRID, IntAct32296183 details
CY561_HUMANECHP_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSMIM1_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTMM11_HUMANBioGRID, IntAct32296183 details
CY561_HUMANGIMA5_HUMANBioGRID, IntAct32296183 details
CY561_HUMANSC22A_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTSNA1_HUMANBioGRID32296183 details
CY561_HUMANS38A7_HUMANBioGRID, IntAct32296183 details
CY561_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
CY561_HUMANCDIPT_HUMANBioGRID, IntAct32296183 details
CY561_HUMANLPAR3_HUMANBioGRID, IntAct32296183 details
CY561_HUMANLHPL5_HUMANBioGRID, IntAct32296183 details
CY561_HUMANOPRM_HUMANBioGRID, IntAct32296183 details
CY561_HUMANBEST2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANGOSR2_HUMANBioGRID, IntAct32296183 details
CY561_HUMANGP152_HUMANBioGRID, IntAct32296183 details
CY561_HUMANRNF5_HUMANBioGRID, IntAct25416956 details
CY561_HUMANERG28_HUMANBioGRID, IntAct32296183 details