Entity Details

Primary name BLK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51451
EntryNameBLK_HUMAN
FullNameTyrosine-protein kinase Blk
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesBLK

GO terms

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GOName
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002513 tolerance induction to self antigen
GO:0002576 platelet degranulation
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006974 cellular response to DNA damage stimulus
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030889 negative regulation of B cell proliferation
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032024 positive regulation of insulin secretion
GO:0035556 intracellular signal transduction
GO:0043304 regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0070667 negative regulation of mast cell proliferation
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:2000670 positive regulation of dendritic cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035853 Tyrosine-protein kinase Blk, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613375 OMIMMaturity-onset diabetes of the young 11 (MODY11)A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
BLK_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
BLK_HUMANEGFR_HUMANBioGRID, IntAct, MINT16273093 22973453 24658140 25402006 31980649 details
BLK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
BLK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
BLK_HUMANKIT_HUMANBioGRID, IntAct24728074 details
BLK_HUMANMET_HUMANBioGRID, IntAct24728074 details
BLK_HUMANEFS_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
BLK_HUMANSTAT3_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
BLK_HUMANP85A_HUMANBioGRID, IntAct32296183 details
BLK_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANPAXI_HUMANBioGRID, IntAct32296183 details
BLK_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
BLK_HUMANTYDP2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
BLK_HUMANZBT8A_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSLAP1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSTAP2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFXR1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFXR2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANP55G_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSOCS3_HUMANBioGRID, IntAct32296183 details
BLK_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSSBP3_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFACC1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANBIRC2_HUMANBioGRID, IntAct32296183 details
BLK_HUMANZBT42_HUMANBioGRID, IntAct32296183 details
BLK_HUMANJKIP1_HUMANBioGRID, IntAct32296183 details
BLK_HUMANGRB10_HUMANBioGRID, IntAct32296183 details
BLK_HUMANCRKL_HUMANBioGRID, IntAct32296183 details
BLK_HUMANSH21B_HUMANBioGRID, IntAct32296183 details
BLK_HUMANZN774_HUMANBioGRID, IntAct32296183 details
BLK_HUMANFLT3_HUMANMINT28086240 details
BLK_HUMANCCD33_HUMANBioGRID, IntAct25416956 31515488 32296183 details
BLK_HUMANUBE3A_HUMANBioGRID, HPRD10449731 details
BLK_HUMANBCL2_HUMANBioGRID, HPRD9525867 details
BLK_HUMANB2CL1_HUMANBioGRID9525867 details
BLK_HUMANPLCG2_HUMANBioGRID, HPRD8395016 details
BLK_HUMANFBX7_HUMANBioGRID27503909 details
BLK_HUMANSKAP2_HUMANBioGRID29568343 details
BLK_HUMANZBT32_HUMANBioGRID32296183 details
BLK_HUMANZMAT1_HUMANBioGRID32296183 details
BLK_HUMANERBB3_HUMANBioGRID22973453 details
BLK_HUMANERBB4_HUMANBioGRID22973453 details
BLK_HUMANSOCS1_HUMANBioGRID31101761 details
BLK_HUMANSPF27_HUMANHPRD12406557 details
BLK_HUMANCBL_HUMANBioGRID, HPRD, MINT8083187 8621719 details
BLK_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
BLK_HUMANVIME_HUMANBioGRID, IntAct31980649 details
BLK_HUMANBANK1_HUMANUniProt21978998 details
BLK_HUMANCD79A_HUMANBioGRID, HPRD7592958 details
BLK_HUMANCD79B_HUMANBioGRID, HPRD7592958 details
BLK_HUMANTRAF3_HUMANBioGRID32779804 details
BLK_HUMANTULP3_HUMANBioGRID33187986 details
BLK_HUMANCTR9_HUMANHPRD8636124 details
BLK_HUMANFCG2B_HUMANHPRD8756631 details
BLK_HUMANFCG2A_HUMANHPRD8756631 details
BLK_HUMANBCR_HUMANHPRD8756631 details