Entity Details

Primary name ARF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP84077
EntryNameARF1_HUMAN
FullNameADP-ribosylation factor 1
TaxID9606
Evidenceevidence at protein level
Length181
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesARF1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000287 magnesium ion binding
GO:0002090 regulation of receptor internalization
GO:0003723 RNA binding
GO:0005525 GTP binding
GO:0005770 late endosome
GO:0005778 peroxisomal membrane
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006878 cellular copper ion homeostasis
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007015 actin filament organization
GO:0014069 postsynaptic density
GO:0016192 vesicle-mediated transport
GO:0019003 GDP binding
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019904 protein domain specific binding
GO:0030017 sarcomere
GO:0030137 COPI-coated vesicle
GO:0031252 cell leading edge
GO:0032991 protein-containing complex
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
GO:0034379 very-low-density lipoprotein particle assembly
GO:0035722 interleukin-12-mediated signaling pathway
GO:0043005 neuron projection
GO:0045807 positive regulation of endocytosis
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0050690 regulation of defense response to virus by virus
GO:0050714 positive regulation of protein secretion
GO:0055108 Golgi to transport vesicle transport
GO:0060292 long-term synaptic depression
GO:0060999 positive regulation of dendritic spine development
GO:0070062 extracellular exosome
GO:0070142 synaptic vesicle budding
GO:0097061 dendritic spine organization
GO:0097212 lysosomal membrane organization
GO:0098586 cellular response to virus
GO:0098974 postsynaptic actin cytoskeleton organization
GO:0098978 glutamatergic synapse
GO:1902307 positive regulation of sodium ion transmembrane transport
GO:1902824 positive regulation of late endosome to lysosome transport
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
GO:1903725 regulation of phospholipid metabolic process
GO:1990386 mitotic cleavage furrow ingression
GO:1990583 phospholipase D activator activity

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Golgi apparatus
Membrane

Domains

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DomainNameCategoryType
IPR005225 Small GTP-binding protein domainDomainDomain
IPR006689 Small GTPase superfamily, ARF/SAR typeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618185 OMIMPeriventricular nodular heterotopia 8 (PVNH8)A form of periventricular nodular heterotopia, a disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches. PVNH8 is an autosomal dominant disease characterized by developmental disabilities, speech delay, seizures and attention deficit hyperactivity disorder. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB02774 1,3-PropanediolDrugbanksmall molecule
DB04121 Guanosine-3'-monophosphate-5'-diphosphateDrugbanksmall molecule
DB04137 Guanosine-5'-TriphosphateDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB07348 Brefeldin ADrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB09462 GlycerinDrugbanksmall molecule

Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
ARF1_HUMANGGA1_HUMANBioGRID, HPRD, IntAct10747089 11950392 12636914 15143060 21198641 details
ARF1_HUMANCYH2_HUMANBioGRID, DIP, HPRD, IntAct10198630 14654833 17563369 9417041 details
ARF1_HUMANEF1G_HUMANBioGRID, HPRD, IntAct16169070 details
ARF1_HUMANWBP11_HUMANBioGRID, HPRD, IntAct16169070 details
ARF1_HUMANNOA1_HUMANBioGRID, HPRD, IntAct16169070 details
ARF1_HUMANJIP4_HUMANMINT19644450 details
ARF1_HUMANT106A_HUMANBioGRID, IntAct21988832 details
ARF1_HUMANAP1B1_HUMANBioGRID, HPRD, IntAct11926829 23415225 details
ARF1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
ARF1_HUMANARF1_HUMANBioGRID, DIP, HPRD18689681 7552752 7990146 7990966 details
ARF1_HUMANARFP2_HUMANBioGRID, HPRD, IntAct31467278 9038142 details
ARF1_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
ARF1_HUMANARFP1_HUMANBioGRID, HPRD, IntAct22981988 9038142 details
ARF1_HUMANGGA3_HUMANBioGRID, HPRD10747089 11301005 11950392 28100775 details
ARF1_HUMANACM3_HUMANBioGRID, HPRD12799371 details
ARF1_HUMANPLD2_HUMANBioGRID, HPRD10801846 11373276 12519790 details
ARF1_HUMANCOPB_HUMANBioGRID, HPRD10318838 10720466 10921873 15202998 16332543 details
ARF1_HUMANAP1G1_HUMANBioGRID, HPRD11926829 details
ARF1_HUMANAP3S2_HUMANBioGRID11926829 details
ARF1_HUMANCOPE_HUMANBioGRID, HPRD10921873 details
ARF1_HUMANAP4M1_HUMANBioGRID, HPRD11707398 details
ARF1_HUMANAP4E1_HUMANBioGRID, HPRD11707398 details
ARF1_HUMANRALA_HUMANBioGRID, HPRD12509462 9688545 details
ARF1_HUMANERD21_HUMANBioGRID, HPRD11703931 details
ARF1_HUMANGGA2_HUMANBioGRID, HPRD10747089 11950392 details
ARF1_HUMANARFG1_HUMANBioGRID, HPRD16332543 19020038 26344197 9733781 details
ARF1_HUMANPKHA8_HUMANBioGRID, HPRD15107860 details
ARF1_HUMANAGAP1_HUMANBioGRID16332543 22453919 details
ARF1_HUMANAGAP2_HUMANBioGRID22453919 details
ARF1_HUMANASAP1_HUMANBioGRID, HPRD16223492 16332543 details
ARF1_HUMAN5HT2A_HUMANBioGRID14573774 16545942 details
ARF1_HUMANAP3B1_HUMANBioGRID, HPRD11926829 15469849 details
ARF1_HUMANGORAB_HUMANBioGRID30631079 details
ARF1_HUMANSCYL1_HUMANBioGRID30631079 details
ARF1_HUMANPICK1_HUMANHPRD10623590 details
ARF1_HUMANPLIN2_HUMANHPRD15336557 details
ARF1_HUMANRHG21_HUMANHPRD15793564 17347647 details
ARF1_HUMANMYC_HUMANMINT17289033 details
ARF1_HUMANSNP25_HUMANMINT30610939 details
ARF1_HUMANCOPG1_HUMANBioGRID, HPRD10720466 details
ARF1_HUMANPLD1_HUMANBioGRID, HPRD26344197 9688545 details
ARF1_HUMANOPRM_HUMANBioGRID12519790 details
ARF1_HUMANHERC1_HUMANBioGRID8861955 details
ARF1_HUMANAPRIO_HUMANBioGRID25896910 details
ARF1_HUMANPRIO_HUMANBioGRID25896910 details
ARF1_HUMANPAXI_HUMANBioGRID16332543 details
ARF1_HUMANINSR_HUMANHPRD9197239 details
ARF1_HUMANGOSR2_HUMANHPRD15781476 details
ARF1_HUMANNPM_HUMANHPRD14636574 15684379 details
ARF1_HUMANCYH1_HUMANHPRD10212218 9653114 9756891 details
ARF1_HUMANMDM4_HUMANHPRD11297540 details
ARF1_HUMANPI51A_HUMANHPRD10589680 10747863 details
ARF1_HUMANASAP2_HUMANHPRD10022920 10749932 details
ARF1_HUMANAP3D1_HUMANHPRD11926829 details
ARF1_HUMANTMEDA_HUMANHPRD11726511 details
ARF1_HUMANTMED2_HUMANHPRD11703931 details