Entity Details

Primary name CNTN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02246
EntryNameCNTN2_HUMAN
FullNameContactin-2
TaxID9606
Evidenceevidence at protein level
Length1040
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesCNTN2

GO terms

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GOName
GO:0005886 plasma membrane
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007411 axon guidance
GO:0030424 axon
GO:0033268 node of Ranvier
GO:0042802 identical protein binding
GO:0043209 myelin sheath
GO:0044224 juxtaparanode region of axon
GO:0045163 clustering of voltage-gated potassium channels
GO:0045202 synapse
GO:0070593 dendrite self-avoidance
GO:0071205 protein localization to juxtaparanode region of axon
GO:0097090 presynaptic membrane organization
GO:0098632 cell-cell adhesion mediator activity
GO:0099025 anchored component of postsynaptic membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR032991 Contactin-2FamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR043204 Basigin-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
615400 OMIMEpilepsy, familial adult myoclonic, 5 (FAME5)A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME5 is characterized by onset of seizures in adolescence, followed by the development of cortical myoclonic tremor later in life. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.