Entity Details

Primary name ACACA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13085
EntryNameACACA_HUMAN
FullNameAcetyl-CoA carboxylase 1
TaxID9606
Evidenceevidence at protein level
Length2346
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesACACA

GO terms

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GOName
GO:0001650 fibrillar center
GO:0001894 tissue homeostasis
GO:0003989 acetyl-CoA carboxylase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006084 acetyl-CoA metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006853 carnitine shuttle
GO:0015629 actin cytoskeleton
GO:0019216 regulation of lipid metabolic process
GO:0019538 protein metabolic process
GO:0031325 positive regulation of cellular metabolic process
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046949 fatty-acyl-CoA biosynthetic process
GO:0051289 protein homotetramerization
GO:0055088 lipid homeostasis
GO:0071380 cellular response to prostaglandin E stimulus
GO:2001295 malonyl-CoA biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000089 Biotin/lipoyl attachmentDomainDomain
IPR001882 Biotin-binding siteSiteBinding site
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domainDomainDomain
IPR005481 Biotin carboxylase-like, N-terminal domainDomainDomain
IPR005482 Biotin carboxylase, C-terminalDomainDomain
IPR011053 Single hybrid motifFamilyHomologous superfamily
IPR011054 Rudiment single hybrid motifFamilyHomologous superfamily
IPR011761 ATP-grasp foldDomainDomain
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminalDomainDomain
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminalDomainDomain
IPR011764 Biotin carboxylation domainDomainDomain
IPR013537 Acetyl-CoA carboxylase, central domainDomainDomain
IPR013815 ATP-grasp fold, subdomain 1FamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR029045 ClpP/crotonase-like domain superfamilyFamilyHomologous superfamily
IPR034733 Acetyl-CoA carboxylaseDomainDomain

Diseases

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Disease IDSourceNameDescription
613933 OMIMAcetyl-CoA carboxylase 1 deficiency (ACACAD)An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00121 BiotinDrugbanksmall molecule

Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
ACACA_HUMANSCG1_HUMANBioGRID, HPRD, IntAct16169070 details
ACACA_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 details
ACACA_HUMANBRCA1_HUMANBioGRID, DIP, HPRD, IntAct12360400 16326698 16698035 18452305 19061860 24565757 29899443 30257991 details
ACACA_HUMANAAPK1_HUMANBioGRID, HPRD, IntAct11052978 18480843 23455922 2900138 7907095 details
ACACA_HUMANFGF14_HUMANBioGRID, IntAct32296183 details
ACACA_HUMANRHBD2_HUMANIntAct32296183 details
ACACA_HUMANAPOC1_HUMANBioGRID, IntAct32296183 details
ACACA_HUMANSIK2_HUMANIntAct27478041 details
ACACA_HUMANACACA_HUMANBioGRID, DIP20457939 29899443 details
ACACA_HUMANPCNA_HUMANUniProt26030842 details
ACACA_HUMANAAKB1_HUMANBioGRID18480843 details
ACACA_HUMANAAKG1_HUMANBioGRID18480843 details
ACACA_HUMANCRCM_HUMANIntAct17353931 details
ACACA_HUMANILK_HUMANBioGRID, IntAct17353931 23455922 details
ACACA_HUMANMYC_HUMANBioGRID, IntAct17353931 21150319 29467282 details
ACACA_HUMANCIAO1_HUMANIntAct17353931 details
ACACA_HUMANAK1BA_HUMANBioGRID, IntAct18056116 details
ACACA_HUMANSIR1_HUMANBioGRID, IntAct19343720 details
ACACA_HUMANAAPK2_HUMANBioGRID, HPRD11052978 20562859 2900138 details
ACACA_HUMANAF9_HUMANBioGRID20431927 details
ACACA_HUMANENL_HUMANBioGRID20431927 details
ACACA_HUMANNPM_HUMANBioGRID20431927 details
ACACA_HUMANUBE2N_HUMANBioGRID18678647 details
ACACA_HUMANELP1_HUMANBioGRID18303054 details
ACACA_HUMANCAH9_HUMANBioGRID23181366 details
ACACA_HUMANCSK21_HUMANHPRD2900140 details
ACACA_HUMANCSK22_HUMANHPRD2900140 details