Entity Details

Primary name STIM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13586
EntryNameSTIM1_HUMAN
FullNameStromal interaction molecule 1
TaxID9606
Evidenceevidence at protein level
Length685
SequenceStatuscomplete
DateCreated2001-11-02
DateModified2021-06-02

Ontological Relatives

GenesSTIM1

GO terms

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GOName
GO:0002020 protease binding
GO:0002115 store-operated calcium entry
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005513 detection of calcium ion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0032237 activation of store-operated calcium channel activity
GO:0032541 cortical endoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane
GO:0042802 identical protein binding
GO:0044853 plasma membrane raft
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045766 positive regulation of angiogenesis
GO:0051010 microtubule plus-end binding
GO:0051924 regulation of calcium ion transport
GO:0070166 enamel mineralization
GO:1903779 regulation of cardiac conduction
GO:2001256 regulation of store-operated calcium entry

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Sarcoplasmic reticulum

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR030463 Stromal interaction molecule 1FamilyFamily
IPR032393 Stromal interaction molecule, Orai1-activating regionDomainDomain
IPR037608 Stromal interaction moleculeFamilyFamily
IPR037609 Stromal interaction molecule 1, SAM domainDomainDomain

Diseases

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Disease IDSourceNameDescription
160565 OMIMMyopathy, tubular aggregate, 1 (TAM1)A rare congenital myopathy characterized by regular arrays of membrane tubules on muscle biopsies without additional histopathological hallmarks. Tubular aggregates in muscle are structures of variable appearance consisting of an outer tubule containing either one or more microtubule-like structures or amorphous material. They may occur in a variety of circumstances, including inherited myopathies, alcohol- and drug-induced myopathies, exercise-induced cramps or muscle weakness. The disease is caused by variants affecting the gene represented in this entry.
185070 OMIMStormorken syndrome (STRMK)A rare autosomal dominant disease characterized by mild bleeding tendency, thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis. The disease is caused by variants affecting the gene represented in this entry.
612783 OMIMImmunodeficiency 10 (IMD10)An immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition. The disease is caused by variants affecting the gene represented in this entry.

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
STIM1_HUMANSTIM1_HUMANDIP, HPRD, IntAct, MINT, UniProt11983428 17517596 19249086 20418871 21427704 22451904 24996186 details
STIM1_HUMANKAT5_HUMANIntAct32814053 details
STIM1_HUMANCRCM1_HUMANDIP, IntAct, MINT, UniProt19249086 19706554 20418871 21427704 21876174 22451904 22464749 24954132 24996186 details
STIM1_HUMANEFC4B_HUMANUniProt20418871 details
STIM1_HUMANINGR1_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANPPIB_HUMANIntAct32814053 details
STIM1_HUMANSL7A1_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANFGFR3_HUMANIntAct32814053 details
STIM1_HUMANRASH_HUMANIntAct32814053 details
STIM1_HUMAN1433G_HUMANIntAct32814053 details
STIM1_HUMANINSI2_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANPRAF1_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANUBQL1_HUMANIntAct32814053 details
STIM1_HUMANSETB1_HUMANIntAct32814053 details
STIM1_HUMANOPTN_HUMANIntAct32814053 details
STIM1_HUMANPPIA_HUMANIntAct32814053 details
STIM1_HUMANLMO3_HUMANIntAct32814053 details
STIM1_HUMANPDIA3_HUMANMINT21941299 details
STIM1_HUMANNMDE3_HUMANIntAct32814053 details
STIM1_HUMANORAI3_HUMANDIP19706554 details
STIM1_HUMANSTIM2_HUMANBioGRID, HPRD, IntAct11463338 28514442 34079125 details
STIM1_HUMANMARE1_HUMANBioGRID, IntAct19632184 23698468 34079125 details
STIM1_HUMANSARAF_HUMANIntAct22464749 details
STIM1_HUMANORAI2_HUMANDIP19706554 details
STIM1_HUMANST7_HUMANBioGRID29395067 details
STIM1_HUMANEXOC5_HUMANBioGRID, IntAct27173435 unassigned1312 details
STIM1_HUMANAT2B4_HUMANMINT22246182 details
STIM1_HUMANTRPC1_HUMANDIP19897728 21408196 details
STIM1_HUMANAT2C1_HUMANIntAct20887894 details