Entity Details

Primary name H3-3A
Entity type gene
Source Source Link

Details

PrimaryID3020
RefseqGeneNG_065173
SymbolH3-3A
NameH3.3 histone A
Chromosome1
Location1q42.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsH33_HUMAN

GO terms

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GOName
GO:0000183 rDNA heterochromatin assembly
GO:0000228 nuclear chromosome
GO:0000781 chromosome, telomeric region
GO:0000786 nucleosome
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001649 osteoblast differentiation
GO:0001740 Barr body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006334 nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006997 nucleus organization
GO:0007286 spermatid development
GO:0007338 single fertilization
GO:0007566 embryo implantation
GO:0007596 blood coagulation
GO:0008283 cell population proliferation
GO:0008584 male gonad development
GO:0030307 positive regulation of cell growth
GO:0031492 nucleosomal DNA binding
GO:0031508 pericentric heterochromatin assembly
GO:0031509 subtelomeric heterochromatin assembly
GO:0032200 telomere organization
GO:0032991 protein-containing complex
GO:0035264 multicellular organism growth
GO:0042692 muscle cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0046982 protein heterodimerization activity
GO:0048477 oogenesis
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060964 regulation of gene silencing by miRNA
GO:0070062 extracellular exosome
GO:0090230 regulation of centromere complex assembly
GO:1900051 positive regulation of histone exchange
GO:1902340 negative regulation of chromosome condensation
GO:1990000 amyloid fibril formation

Diseases

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Disease IDSourceNameDescription
137800 OMIMGlioma (GLM)Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. The gene represented in this entry is involved in disease pathogenesis. H3F3A mutations affecting residues involved in post-translational modifications of histone H3.3 are recurrent in malignant, aggressive gliomas including glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG) (PubMed:22286061, PubMed:22286216). The mechanism through which mutations lead to tumorigenesis involves altered histones methylation, impaired regulation of Polycomb repressive complex 2 (PRC2) activity, and aberrant epigenetic regulation of gene expression (PubMed:23539269, PubMed:23539183, PubMed:23603901).

Interactions

207 interactions

InteractorPartnerSourcesPublicationsLink
H3-3ACBX5BioGRID, MINT17403666 19834512 24981860 details
H3-3ADNMT3AMINT19834512 details
H3-3ADNMT3LMINT19834512 details
H3-3ADAXXBioGRID, DIP, IntAct, MINT20211137 20504901 20651253 21047901 23075851 23142979 23222847 23828041 24209620 24530302 24981860 25275136 27217568 27626385 32296183 details
H3-3AATRXBioGRID, IntAct20110566 20211137 20504901 20651253 24530302 24981860 25538301 29937341 details
H3-3APELP1BioGRID, MINT20448663 27626385 details
H3-3ANOS3BioGRID, IntAct21163940 details
H3-3ATAF3MINT20953165 details
H3-3ABPTFBioGRID, HPRD, MINT16728976 16728978 20953165 details
H3-3APHF21AMINT20953165 details
H3-3ACBX3BioGRID, IntAct17403666 22684280 27705803 details
H3-3ANASPBioGRID, IntAct14718166 20504901 25416956 28514442 details
H3-3ACBX6DIP18927235 details
H3-3ACBX2DIP18927235 details
H3-3ACBX4BioGRID, DIP18927235 26496610 details
H3-3ACBX7DIP18927235 details
H3-3ACBX8DIP18927235 details
H3-3AASF1BBioGRID, DIP, HPRD14718166 15664198 20504901 20651253 23075851 24209620 26167883 details
H3-3AASF1ABioGRID, DIP, HPRD14718166 15664198 18971269 20504901 23075851 23828041 24209620 27217568 details
H3-3AH3-3ADIP23075851 details
H3-3AH3-3BDIP23075851 details
H3-3AHMGB2BioGRID, UniProt29721183 details
H3-3ASSRP1BioGRID17403666 21969370 details
H3-3APARP1BioGRID17403666 20504901 20525793 28190768 details
H3-3APARP2BioGRID20504901 28190768 details
H3-3AUBN1BioGRID21047901 22195966 26159857 27217568 details
H3-3AKMT2ABioGRID17166833 details
H3-3ASETD7BioGRID17166833 details
H3-3ABRD1BioGRID21880731 27142060 details
H3-3AZMYND11BioGRID24590075 details
H3-3ASUV39H1BioGRID17172641 details
H3-3AESR1BioGRID20348541 details
H3-3AMLLT3BioGRID25417107 details
H3-3AHPF1BioGRID28190768 details
H3-3APIM1BioGRID28620180 details
H3-3APPP1CABioGRID23828041 details
H3-3APPP1CBBioGRID23828041 details
H3-3APPM1DBioGRID23828041 details
H3-3ANEDD4BioGRID28300060 details
H3-3AEP300BioGRID27626385 28300060 details
H3-3ASETBioGRID27626385 details
H3-3ADCAF1BioGRID27626385 details
H3-3ABRD4BioGRID27626385 32416067 details
H3-3ABRD7BioGRID27626385 details
H3-3AEHMT2BioGRID, IntAct16189514 17403666 details
H3-3AHIRABioGRID, IntAct14718166 19410545 20211137 21047901 22195966 24209620 details
H3-3ARBBP4BioGRID, IntAct14718166 19410545 27705803 details
H3-3AING2MINT20953165 details
H3-3AING4MINT20953165 details
H3-3ANOC2LUniProt16322561 details
H3-3ACBX1BioGRID, IntAct17403666 27705803 details
H3-3AH4-16BioGRID, DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C15DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C9DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C1BioGRID, DIP, IntAct14718166 23075851 23142979 24183680 24530302 26167883 details
H3-3AH4C4DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C6BioGRID, DIP, IntAct21724829 23075851 23142979 24183680 26167883 details
H3-3AH4C12DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C11DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C3DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C8DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C2DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C5DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C13DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3AH4C14DIP, IntAct23075851 23142979 24183680 26167883 details
H3-3ADYNC2I1BioGRID, IntAct27173435 unassigned1312 details
H3-3ADYNC2I2BioGRID, IntAct27173435 unassigned1312 details
H3-3ACHAF1ABioGRID, DIP23075851 details
H3-3AH3C14BioGRID, IntAct24981860 30021884 details
H3-3AH3C15IntAct30021884 details
H3-3AH3C13IntAct30021884 details
H3-3ACACNA2D1IntAct30021884 details
H3-3AREV3LIntAct30021884 details
H3-3AH2AC8IntAct30021884 details
H3-3AH2AC4IntAct30021884 details
H3-3AHMGB1BioGRID, UniProt17403666 29721183 details
H3-3ACENPABioGRID15009096 24530302 details
H3-3AIPO4BioGRID14718166 details
H3-3AHAT1BioGRID14718166 20504901 24981860 details
H3-3AASH1LBioGRID17403666 details
H3-3ACARM1BioGRID, HPRD11751582 17403666 details
H3-3AEHMT1BioGRID17403666 details
H3-3AKMT2CBioGRID17403666 details
H3-3AKDM4CBioGRID17403666 details
H3-3AHDAC5BioGRID17403666 details
H3-3AHDAC9BioGRID17403666 details
H3-3ANCLBioGRID17403666 details
H3-3ASUPT16HBioGRID, HPRD15616580 17403666 details
H3-3ACHD4BioGRID17403666 details
H3-3ASF3B1BioGRID17403666 details
H3-3ATHRAP3BioGRID17403666 details
H3-3ASAP130BioGRID17403666 details
H3-3ATRIM28BioGRID17403666 details
H3-3ASF3B2BioGRID17403666 details
H3-3AHNRNPKBioGRID17403666 details
H3-3ACCDC71BioGRID17403666 details
H3-3ARNF41BioGRID17403666 details
H3-3AFBLBioGRID17403666 details
H3-3ADHRS12BioGRID17403666 details
H3-3AH2BC21BioGRID17403666 details
H3-3AH1-5BioGRID17403666 details
H3-3AKAT2BBioGRID, HPRD15616580 20651253 28300060 details
H3-3APRKDCBioGRID20504901 details
H3-3ATOP2ABioGRID20504901 details
H3-3AKPNA4BioGRID20504901 details
H3-3AXRCC5BioGRID20504901 details
H3-3AXRCC6BioGRID20504901 details
H3-3ATOP1BioGRID20504901 details
H3-3ACABIN1BioGRID21047901 22195966 27217568 details
H3-3AKDM4ABioGRID21931800 details
H3-3AITGA4BioGRID22623428 details
H3-3AMACROH2A1BioGRID23319141 24981860 details
H3-3APMLBioGRID23222847 details
H3-3ATFAP2ABioGRID23828041 details
H3-3AKAT2ABioGRID28300060 details
H3-3AFGF2BioGRID22539306 details
H3-3AFGFR1BioGRID22539306 details
H3-3ATHBioGRID22539306 details
H3-3ADPF3BioGRID27402533 details
H3-3ACDKN1ABioGRID27626385 details
H3-3ABBC3BioGRID27626385 details
H3-3AACTG1BioGRID23160995 details
H3-3AH2AXBioGRID24981860 29937341 details
H3-3ASS18HPRD11591653 details
H3-3ATLE2HPRD9334241 details
H3-3AMAPK9HPRD11278789 details
H3-3APARP10HPRD15674325 details
H3-3ACREBBPHPRD15616580 details
H3-3ASMARCA5HPRD15616580 16728976 details
H3-3ACHD1HPRD16728976 details
H3-3ASMARCA1HPRD16728976 details
H3-3AARRB1IntAct17620599 details
H3-3ATAF5MINT20953165 details
H3-3ATAF6MINT20953165 details
H3-3AMYCBioGRID, IntAct21150319 32140074 details
H3-3ACHAF1BBioGRID, IntAct27705803 details
H3-3AEZH2BioGRID, IntAct24183680 27705803 details
H3-3ARBBP7BioGRID, IntAct27705803 details
H3-3ASUZ12IntAct24183680 details
H3-3APKMIntAct24606918 details
H3-3APHACTR3BioGRID, IntAct28330616 details
H3-3AKIF3AIntAct28514442 details
H3-3ASGO2IntAct28514442 details
H3-3ALACC1IntAct28514442 details
H3-3ACHD1LDIP19666485 details
H3-3AMCM2BioGRID, DIP25963833 26167883 details
H3-3AFHBioGRID, DIP26237645 details
H3-3APDHA1BioGRID, IntAct29128334 details
H3-3AMAPTUniProt26269332 details
H3-3ATFAMUniProt22453275 details
H3-3ARALBP1BioGRID, IntAct31980649 details
H3-3ACAMK2ABioGRID, IntAct31980649 details
H3-3AMYLK2BioGRID, IntAct31980649 details
H3-3AELK4BioGRID, IntAct31980649 details
H3-3ARPS6KA3BioGRID, IntAct31980649 details
H3-3ATOP3BBioGRID, MINT24981860 details
H3-3ATSPYL5BioGRID, MINT24981860 details
H3-3AGSK3BUniProt30824926 details
H3-3ALRRK2BioGRID20876399 details
H3-3ACORO1CBioGRID22863883 details
H3-3ANIBAN2BioGRID22863883 details
H3-3ANUDCBioGRID22863883 details
H3-3APAWRBioGRID22863883 details
H3-3APUF60BioGRID22863883 details
H3-3ASNX2BioGRID22863883 details
H3-3ASNX6BioGRID22863883 details
H3-3AVPS26ABioGRID22863883 details
H3-3AVPS29BioGRID22863883 details
H3-3AVPS35BioGRID22863883 details
H3-3AASB2BioGRID24337577 details
H3-3AASB9BioGRID24337577 details
H3-3AASB16BioGRID24337577 details
H3-3AFUSBioGRID25192599 details
H3-3ARNF2BioGRID24457600 details
H3-3AHNRNPA1BioGRID25324306 details
H3-3AMSH6BioGRID26496610 details
H3-3AKIF11BioGRID26496610 details
H3-3APDGFRABioGRID26496610 details
H3-3ARAB5CBioGRID26496610 details
H3-3AAP4M1BioGRID26496610 details
H3-3ACKAP5BioGRID26496610 details
H3-3APOLKBioGRID26496610 details
H3-3ADNAJC11BioGRID26496610 details
H3-3ACAMKK1BioGRID26496610 details
H3-3ACDCA5BioGRID26496610 details
H3-3AHDAC1BioGRID26496610 details
H3-3AMCM5BioGRID25963833 details
H3-3APHIPBioGRID29089422 details
H3-3ARIOK1BioGRID21081503 details
H3-3AHERC2BioGRID29511261 details
H3-3AH3C1BioGRID29568061 details
H3-3ANR2C2BioGRID30463901 details
H3-3AVRK1BioGRID28927264 details
H3-3AVRK3BioGRID28927264 details
H3-3ABIRC3BioGRID30948266 details
H3-3AFANCD2BioGRID31180492 details
H3-3ABRWD3BioGRID31753913 details
H3-3ARNF4BioGRID32521226 details
H3-3AH2BC11BioGRID24981860 details
H3-3AARBioGRID32814769 details
H3-3APRKNBioGRID32929329 details
H3-3AUFL1BioGRID32807901 details
H3-3ADDX23BioGRID34079125 details
H3-3AEMDBioGRID34079125 details
H3-3AEZRBioGRID34079125 details
H3-3ARAB35BioGRID34079125 details
H3-3ARHOBBioGRID34079125 details