Entity Details

Primary name TGIF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15583
EntryNameTGIF1_HUMAN
FullNameHomeobox protein TGIF1
TaxID9606
Evidenceevidence at protein level
Length401
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTGIF1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0010629 negative regulation of gene expression
GO:0042493 response to drug
GO:0070410 co-SMAD binding
GO:0071363 cellular response to growth factor stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR008422 Homeobox KN domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
142946 OMIMHoloprosencephaly 4 (HPE4)A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. The disease is caused by variants affecting the gene represented in this entry.

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
TGIF1_HUMANCTBP1_HUMANBioGRID, HPRD, IntAct, MINT10995736 20361981 25416956 25910212 details
TGIF1_HUMANMED31_HUMANBioGRID, HPRD, IntAct16169070 details
TGIF1_HUMANEF1A1_HUMANBioGRID, HPRD, IntAct16169070 details
TGIF1_HUMANCTBP2_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 25416956 25910212 details
TGIF1_HUMANLEG8_HUMANMINT18511908 details
TGIF1_HUMANPML_HUMANBioGRID, HPRD, MINT16916642 18511908 details
TGIF1_HUMANMDFI_HUMANBioGRID, IntAct, MINT21516116 25416956 details
TGIF1_HUMANA2MG_HUMANBioGRID, MINT21900206 details
TGIF1_HUMANAXIN2_HUMANIntAct25873176 details
TGIF1_HUMANFMR1_HUMANIntAct32814053 details
TGIF1_HUMANP85A_HUMANIntAct32814053 details
TGIF1_HUMANPNPH_HUMANIntAct32814053 details
TGIF1_HUMANSMAD3_HUMANBioGRID, IntAct11306568 11427533 32814053 details
TGIF1_HUMANVPS29_HUMANIntAct32814053 details
TGIF1_HUMANPLK1_HUMANIntAct32814053 details
TGIF1_HUMANPLPP1_HUMANIntAct32814053 details
TGIF1_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
TGIF1_HUMANSMAD2_HUMANBioGRID, HPRD10199400 11371641 18511908 details
TGIF1_HUMANLRIF1_HUMANBioGRID, HPRD16169070 details
TGIF1_HUMANJUN_HUMANBioGRID, HPRD11371641 details
TGIF1_HUMANANDR_HUMANBioGRID, HPRD11682623 details
TGIF1_HUMANSIN3A_HUMANBioGRID, HPRD11416139 11682623 details
TGIF1_HUMANMOB3A_HUMANBioGRID21516116 details
TGIF1_HUMANI2BP1_HUMANHPRD18511908 details
TGIF1_HUMANRIF1_HUMANIntAct16169070 details
TGIF1_HUMANAXIN1_HUMANIntAct25873176 details
TGIF1_HUMANCTNB1_HUMANIntAct25873176 details
TGIF1_HUMANHDAC1_HUMANBioGRID, HPRD10995736 11226163 11427533 18511908 details
TGIF1_HUMANSMAD1_HUMANBioGRID10199400 details
TGIF1_HUMANFOXH1_HUMANBioGRID10199400 details
TGIF1_HUMANMK01_HUMANHPRD11226163 details
TGIF1_HUMANMK03_HUMANHPRD11226163 details
TGIF1_HUMANWWP1_HUMANHPRD18511908 details
TGIF1_HUMANHMGB1_HUMANHPRD11748221 details