Entity Details

Primary name ROR1
Entity type gene
Source Source Link

Details

PrimaryID4919
RefseqGeneNG_032801
SymbolROR1
Namereceptor tyrosine kinase like orphan receptor 1
Chromosome1
Location1p31.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-25
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsROR1_HUMAN

GO terms

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GOName
GO:0001725 stress fiber
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007605 sensory perception of sound
GO:0009986 cell surface
GO:0010976 positive regulation of neuron projection development
GO:0014002 astrocyte development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017147 Wnt-protein binding
GO:0033674 positive regulation of kinase activity
GO:0042813 Wnt-activated receptor activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043679 axon terminus
GO:0048839 inner ear development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway

Diseases

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Disease IDSourceNameDescription
617654 OMIMDeafness, autosomal recessive, 108 (DFNB108)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.