Entity Details

Primary name THPO
Entity type gene
Source Source Link

Details

PrimaryID7066
RefseqGeneNG_012136
SymbolTHPO
Namethrombopoietin
Chromosome3
Location3q27.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-03
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTPO_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007275 multicellular organism development
GO:0008083 growth factor activity
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0035855 megakaryocyte development
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097696 receptor signaling pathway via STAT
GO:1902035 positive regulation of hematopoietic stem cell proliferation

Diseases

Show/Hide Table
Disease IDSourceNameDescription
187950 OMIMThrombocythemia 1 (THCYT1)A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
THPOEP300BioGRID, IntAct21988832 details
THPONUMBLBioGRID, IntAct21988832 details
THPOAPH1ABioGRID, IntAct21988832 details
THPOMPLHPRD9766811 details