Entity Details

Primary name KANK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ63ZY3
EntryNameKANK2_HUMAN
FullNameKN motif and ankyrin repeat domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length851
SequenceStatuscomplete
DateCreated2006-06-27
DateModified2021-06-02

Ontological Relatives

GenesKANK2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035023 regulation of Rho protein signal transduction
GO:0043069 negative regulation of programmed cell death
GO:0070563 negative regulation of vitamin D receptor signaling pathway
GO:0072073 kidney epithelium development
GO:0090521 glomerular visceral epithelial cell migration
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR021939 Kank N-terminal motifSiteConserved site
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617783 OMIMNephrotic syndrome 16 (NPHS16)A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form that progresses to end-stage renal failure. NPHS16 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.
616099 OMIMPalmoplantar keratoderma and woolly hair (PPKWH)A disorder characterized by abnormal thickening of the skin on the palms and soles, in association with woolly scalp hair. Affected individuals manifest a variable degree of striate palmoplantar keratoderma, generally more severe on the soles. Leukonychia is more pronounced on the fingernails than toenails. Scalp hair, body hair, eyebrows, and eyelashes are sparse. The fifth toes show variable degrees of pseudoainhum, ranging from external rotation to a deep sulcus at the digitoplantar fold, accompanied by a bulbous appearance of the distal toe. The disease is caused by variants affecting the gene represented in this entry.

Interactions

199 interactions

InteractorPartnerSourcesPublicationsLink
KANK2_HUMANGOGA2_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
KANK2_HUMANLBX1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZN648_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCARD9_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGEMI_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZN417_HUMANIntAct32296183 details
KANK2_HUMANPRR5L_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPSB4_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZN512_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANFHL3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZN414_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANKIFA3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANKRT86_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANSCAR5_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANABI3_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANKIFC3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPHS_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANLENG1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANAEN_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCINP_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANASB15_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANRFIP2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANHSPB2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGO45_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANSNAPN_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANHAND2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPPIP1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMED19_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANUBAP2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANDYL1_HUMANBioGRID, IntAct25416956 26496610 32296183 details
KANK2_HUMANFHL2_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANTHAP1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANG45IP_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCDKL3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANDLGP3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPRD14_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGRB10_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGMCL1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANK1C40_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANLZTS1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCCD57_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTSG10_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANBIRC7_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTGM5_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMAGB4_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANRBTN2_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANTXLNA_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANCEP70_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANWASF3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANSTAC_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANSYT6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCAN3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANFKBP6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCOG6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCDC5L_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANSNW1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCEP63_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANVWC2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTLE5_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANCB068_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANSRTD3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGPKOW_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTRAF4_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMSS51_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANC19L2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTHAP6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTAXB1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANF161A_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCD20B_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANIL16_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANAL14E_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZN774_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANUSBP1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANNCOA5_HUMANBioGRID32296183 details
KANK2_HUMANZN212_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANK1C27_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCBX8_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGEMI4_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPLAL2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANLHX3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPFD6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANIF4E_HUMANBioGRID, IntAct24722188 25416956 32296183 details
KANK2_HUMANKIF9_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZN784_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCUTC_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANEFHC2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANEXOS8_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTRAF2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANRNF8_HUMANIntAct32296183 details
KANK2_HUMANLHX1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCC88B_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMYOZ3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMEOX1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANHOME3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANKCC2G_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANIHO1_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANDTX2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPLAL1_HUMANIntAct32296183 details
KANK2_HUMANCDK18_HUMANIntAct32296183 details
KANK2_HUMANMNS1_HUMANIntAct32296183 details
KANK2_HUMANZMAT2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPDE9A_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMORN3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZFP57_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCEAM6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCCD33_HUMANBioGRID25416956 32296183 details
KANK2_HUMANPKHA2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMITD1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPRP31_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANT10IP_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMTUS2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGATA1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANVINEX_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANBEND7_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPAX6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANRBP1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTIFA_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTEX11_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANDYL2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTRI35_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANRBTN1_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANLMO4_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANMOB1A_HUMANBioGRID, IntAct25416956 32296183 details
KANK2_HUMANTOP3B_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGPAN1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCRX_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPRP18_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTRAF1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANLMBL3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCEP55_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPSN1_HUMANBioGRID, IntAct21163940 details
KANK2_HUMANKANK2_HUMANBioGRID, IntAct25416956 details
KANK2_HUMANELOA1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANBORC6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANNECA2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPP1B_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPDLI7_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPRDM6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANANM5_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCAR10_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZBT42_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZNHI1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANNOS3_HUMANBioGRID, IntAct21163940 details
KANK2_HUMANVPS52_HUMANBioGRID, IntAct25416956 details
KANK2_HUMANGPSM1_HUMANBioGRID, IntAct25416956 details
KANK2_HUMANKAP1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMOB3C_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTSYL6_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMCCD1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGOG6A_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCHIC2_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANK2C75_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANDP2NB_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANNCOA1_HUMANBioGRID, MINT17476305 details
KANK2_HUMANCSK21_HUMANBioGRID, MINT17476305 details
KANK2_HUMANUT14C_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANPNKP_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANCK001_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMEOX2_HUMANBioGRID32296183 details
KANK2_HUMANNUTM1_HUMANBioGRID32296183 details
KANK2_HUMANAP2B1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANHOIL1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANABT1_HUMANIntAct32296183 details
KANK2_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANVMAC_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTRIB3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMCRS1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANLMO3_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANSCNM1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGA2L2_HUMANIntAct32296183 details
KANK2_HUMANMIC19_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANWASH1_HUMANBioGRID32296183 details
KANK2_HUMANCYH4_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANTRI54_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANMS18B_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANNELFE_HUMANIntAct32296183 details
KANK2_HUMANRHOH_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGKAP1_HUMANBioGRID, IntAct32296183 details
KANK2_HUMANGNL3L_HUMANIntAct32296183 details
KANK2_HUMANSRPK2_HUMANBioGRID26167880 details
KANK2_HUMANCAPS1_HUMANBioGRID32296183 details
KANK2_HUMANANR11_HUMANBioGRID32296183 details
KANK2_HUMANIN80B_HUMANIntAct32296183 details
KANK2_HUMANPIBF1_HUMANBioGRID32296183 details
KANK2_HUMANNCOA2_HUMANBioGRID17476305 details
KANK2_HUMANTNR6A_HUMANBioGRID29395067 details
KANK2_HUMANAIFM1_HUMANUniProt22371500 details
KANK2_HUMANTNR6B_HUMANBioGRID29395067 details
KANK2_HUMANTTP_HUMANBioGRID29395067 details