Entity Details

Primary name CP4FN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6NT55
EntryNameCP4FN_HUMAN
FullNameCytochrome P450 4F22
TaxID9606
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated2007-07-10
DateModified2021-06-02

Ontological Relatives

GenesCYP4F22

GO terms

Show/Hide Table
GOName
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0006690 icosanoid metabolic process
GO:0016021 integral component of membrane
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046513 ceramide biosynthetic process

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
604777 OMIMIchthyosis, congenital, autosomal recessive 5 (ARCI5)A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CP4FN_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
CP4FN_HUMANMSMO1_HUMANBioGRID, IntAct32296183 details
CP4FN_HUMANTLCD4_HUMANBioGRID, IntAct32296183 details
CP4FN_HUMANREEP2_HUMANBioGRID, IntAct32296183 details