Entity Details

Primary name PRP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6P2Q9
EntryNamePRP8_HUMAN
FullNamePre-mRNA-processing-splicing factor 8
TaxID9606
Evidenceevidence at protein level
Length2335
SequenceStatuscomplete
DateCreated2005-06-07
DateModified2021-06-02

Ontological Relatives

GenesPRPF8

GO terms

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GOName
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005682 U5 snRNP
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030623 U5 snRNA binding
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070122 isopeptidase activity
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
GO:0097157 pre-mRNA intronic binding

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000555 JAB1/MPN/MOV34 metalloenzyme domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR012591 PRO8NT domainDomainDomain
IPR012592 PROCN domainDomainDomain
IPR012984 PROCT domainDomainDomain
IPR019580 Pre-mRNA-processing-splicing factor 8, U6-snRNA-bindingDomainDomain
IPR019581 Pre-mRNA-processing-splicing factor 8, U5-snRNA-bindingDomainDomain
IPR019582 RNA recognition motif, spliceosomal PrP8DomainDomain
IPR021983 PRP8 domain IV coreDomainDomain
IPR027652 Pre-mRNA-processing-splicing factor 8FamilyFamily
IPR037518 MPN domainDomainDomain
IPR042516 Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamilyFamilyHomologous superfamily
IPR043172 Prp8 RNase domain IV, palm regionFamilyHomologous superfamily
IPR043173 Prp8 RNase domain IV, fingers regionFamilyHomologous superfamily

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
PRP8_HUMANSNR40_HUMANBioGRID, IntAct, UniProt16723661 17353931 22939629 26186194 26344197 28514442 28515276 34079125 9774689 details
PRP8_HUMANU5S1_HUMANBioGRID, IntAct, UniProt16723661 17317632 22939629 25263594 26344197 27173435 28515276 34079125 9774689 unassigned1312 details
PRP8_HUMANU520_HUMANBioGRID, DIP, IntAct, UniProt16723661 17317632 22939629 23704370 26344197 27173435 28515276 31914407 34079125 9774689 unassigned1312 details
PRP8_HUMANSF3B4_HUMANBioGRID, MINT22365833 28515276 details
PRP8_HUMANSLU7_HUMANBioGRID, MINT22365833 details
PRP8_HUMANPCBP1_HUMANBioGRID, MINT22365833 28515276 details
PRP8_HUMANHNRH2_HUMANBioGRID, MINT22365833 details
PRP8_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
PRP8_HUMANPRP6_HUMANBioGRID, IntAct, UniProt16723661 22939629 26344197 27173435 28515276 34079125 unassigned1312 details
PRP8_HUMANSF3B2_HUMANBioGRID, MINT22365833 28515276 details
PRP8_HUMANTADBP_HUMANIntAct32814053 details
PRP8_HUMANPRP19_HUMANBioGRID, MINT22365833 22939629 26344197 28515276 34079125 details
PRP8_HUMANUBC_HUMANBioGRID20595234 details
PRP8_HUMANSPF27_HUMANBioGRID, MINT22365833 28515276 34079125 details
PRP8_HUMANPAI2_HUMANBioGRID, HPRD15346200 details
PRP8_HUMANPRP8_HUMANBioGRID16723661 17317632 28515276 details
PRP8_HUMANWDR83_HUMANBioGRID, MINT22365833 details
PRP8_HUMANZN830_HUMANBioGRID, MINT22365833 details
PRP8_HUMANSUMO2_HUMANBioGRID32786267 details
PRP8_HUMANECD_HUMANBioGRID, IntAct, UniProt22939629 26711270 28514442 28515276 28561026 34079125 details
PRP8_HUMANGPKOW_HUMANBioGRID, MINT22365833 details
PRP8_HUMANSND1_HUMANBioGRID, DIP17632523 details
PRP8_HUMANPRPF3_HUMANBioGRID20595234 22939629 26344197 28515276 details
PRP8_HUMANERG_HUMANBioGRID21575865 24591637 details
PRP8_HUMANUBC9_HUMANBioGRID19596686 details
PRP8_HUMANABCA1_HUMANBioGRID12054535 details
PRP8_HUMANATX1_HUMANIntAct32814053 details
PRP8_HUMANPIN1_HUMANBioGRID16055720 details
PRP8_HUMANH2B1C_HUMANBioGRID31152661 details
PRP8_HUMANPTEN_HUMANBioGRID31685992 details
PRP8_HUMANS22A2_HUMANBioGRID31318583 details
PRP8_HUMANNEDD4_HUMANBioGRID16055720 details
PRP8_HUMANH2B1D_HUMANBioGRID31152661 details
PRP8_HUMANP53_HUMANBioGRID31152661 32807901 details
PRP8_HUMANBRE1A_HUMANBioGRID31152661 details
PRP8_HUMANSF3A2_HUMANBioGRID, MINT17332742 22939629 details
PRP8_HUMANCD2B2_HUMANBioGRID, IntAct17353931 22939629 26344197 27173435 28514442 28515276 28561026 34079125 unassigned1312 details
PRP8_HUMANNFKB2_HUMANIntAct14743216 details
PRP8_HUMANRIOK1_HUMANBioGRID, IntAct21081503 27173435 unassigned1312 details
PRP8_HUMANSMU1_HUMANBioGRID, IntAct22939629 27173435 28515276 unassigned1312 details
PRP8_HUMANAAR2_HUMANBioGRID, IntAct22939629 26186194 26344197 28514442 28515276 28561026 34079125 details
PRP8_HUMANSNUT1_HUMANBioGRID, IntAct11350945 22939629 26344197 28515276 30021884 details
PRP8_HUMANSRRM1_HUMANBioGRID10809668 16159877 details
PRP8_HUMANZBT7B_HUMANBioGRID20810990 details
PRP8_HUMANDHX9_HUMANBioGRID, HPRD15034300 22939629 28515276 details
PRP8_HUMANSRPK1_HUMANBioGRID15034300 details
PRP8_HUMANU2AF2_HUMANBioGRID26641092 details
PRP8_HUMANTLS1_HUMANBioGRID26472760 28515276 details
PRP8_HUMANGGYF2_HUMANBioGRID20696395 details
PRP8_HUMANSIR6_HUMANBioGRID24169447 details
PRP8_HUMANANDR_HUMANBioGRID26371515 32814769 details
PRP8_HUMANTTC27_HUMANBioGRID26472760 28515276 details
PRP8_HUMANCA131_HUMANBioGRID26472760 details
PRP8_HUMANRPAP3_HUMANBioGRID28515276 34079125 details
PRP8_HUMANITA4_HUMANBioGRID22623428 details
PRP8_HUMANASCC1_HUMANBioGRID29997253 details
PRP8_HUMANRSMB_HUMANBioGRID17353931 28515276 34079125 details
PRP8_HUMANISG15_HUMANBioGRID33024031 details
PRP8_HUMANPRP31_HUMANBioGRID26344197 28088760 28515276 details
PRP8_HUMANZNHI2_HUMANBioGRID28515276 28561026 details
PRP8_HUMANRUVB1_HUMANBioGRID28515276 28561026 34079125 details
PRP8_HUMANHDAC5_HUMANBioGRID21081666 details
PRP8_HUMANRUVB2_HUMANBioGRID28515276 28561026 34079125 details
PRP8_HUMANPHF6_HUMANBioGRID22720776 details