Entity Details

Primary name ABRX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6UWZ7
EntryNameABRX1_HUMAN
FullNameBRCA1-A complex subunit Abraxas 1
TaxID9606
Evidenceevidence at protein level
Length409
SequenceStatuscomplete
DateCreated2007-02-20
DateModified2021-06-02

Ontological Relatives

GenesABRAXAS1

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006325 chromatin organization
GO:0008017 microtubule binding
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0010212 response to ionizing radiation
GO:0016579 protein deubiquitination
GO:0016604 nuclear body
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0045739 positive regulation of DNA repair
GO:0070531 BRCA1-A complex
GO:0070536 protein K63-linked deubiquitination
GO:0090307 mitotic spindle assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR023238 FAM175 familyFamilyFamily
IPR023239 FAM175 family, BRCA1-A complex, Abraxas 1 subunitFamilyFamily
IPR037518 MPN domainDomainDomain

Diseases

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Disease IDSourceNameDescription
114480 OMIMBreast cancer (BC)A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Disease susceptibility is associated with variants affecting the gene represented in this entry.