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Entity Details
Primary name
ABRX1_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q6UWZ7
EntryName
ABRX1_HUMAN
FullName
BRCA1-A complex subunit Abraxas 1
TaxID
9606
Evidence
evidence at protein level
Length
409
SequenceStatus
complete
DateCreated
2007-02-20
DateModified
2021-06-02
Ontological Relatives
Genes
ABRAXAS1
GO terms
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GO
Name
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0006302
double-strand break repair
GO:0006303
double-strand break repair via nonhomologous end joining
GO:0006325
chromatin organization
GO:0008017
microtubule binding
GO:0008608
attachment of spindle microtubules to kinetochore
GO:0010212
response to ionizing radiation
GO:0016579
protein deubiquitination
GO:0016604
nuclear body
GO:0031593
polyubiquitin modification-dependent protein binding
GO:0045739
positive regulation of DNA repair
GO:0070531
BRCA1-A complex
GO:0070536
protein K63-linked deubiquitination
GO:0090307
mitotic spindle assembly
Subcellular Location
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Subcellular Location
Nucleus
Domains
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Domain
Name
Category
Type
IPR023238
FAM175 family
Family
Family
IPR023239
FAM175 family, BRCA1-A complex, Abraxas 1 subunit
Family
Family
IPR037518
MPN domain
Domain
Domain
Diseases
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Disease ID
Source
Name
Description
114480
OMIM
Breast cancer (BC)
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Drugs
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Interactions
16 interactions
Interactor
Partner
Sources
Publications
Link
ABRX1_HUMAN
BRCA1_HUMAN
BioGRID, DIP, HPRD, IntAct, UniProt
17525340
17643121
17643122
19261746
19261748
19261749
19305427
19766185
21282113
22357538
23416467
25184681
26778126
28398198
29656893
30257991
details
ABRX1_HUMAN
UIMC1_HUMAN
BioGRID, DIP, HPRD, IntAct
17525340
17643121
17643122
18077395
19015238
19261746
19261748
19261749
19305427
19615732
20656689
20656690
21282113
22357538
23264621
24075985
25252691
28242625
28569838
details
ABRX1_HUMAN
BRCC3_HUMAN
BioGRID, DIP, IntAct
18077395
19261746
19261748
19261749
19615732
20656689
20656690
21282113
22357538
24075985
details
ABRX1_HUMAN
BABA2_HUMAN
BioGRID, IntAct
19261746
19261748
19261749
19615732
20656689
21282113
24075985
details
ABRX1_HUMAN
BABA1_HUMAN
BioGRID, IntAct
19261746
19261748
19261749
19615732
20656689
21282113
22357538
22792303
24075985
26186194
28514442
details
ABRX1_HUMAN
UBC_HUMAN
BioGRID
16196087
19261749
28190767
details
ABRX1_HUMAN
SUMO2_HUMAN
BioGRID
22689573
23211528
details
ABRX1_HUMAN
ZMYM3_HUMAN
BioGRID
28242625
details
ABRX1_HUMAN
OGT1_HUMAN
BioGRID
32994395
details
ABRX1_HUMAN
CTIP_HUMAN
IntAct
17525340
details
ABRX1_HUMAN
RAD51_HUMAN
IntAct
17525340
details
ABRX1_HUMAN
BARD1_HUMAN
BioGRID
19261748
19261749
25252691
details
ABRX1_HUMAN
HSP74_HUMAN
BioGRID
19261749
details
ABRX1_HUMAN
FANCG_HUMAN
BioGRID
25132264
details
ABRX1_HUMAN
PARP1_HUMAN
BioGRID
25252691
details
ABRX1_HUMAN
ABRX1_HUMAN
BioGRID
26778126
details
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