Entity Details

Primary name STOX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6ZVD7
EntryNameSTOX1_HUMAN
FullNameStorkhead-box protein 1
TaxID9606
Evidenceevidence at protein level
Length989
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesSTOX1

GO terms

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GOName
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0007049 cell cycle
GO:0008284 positive regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010821 regulation of mitochondrion organization
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0051301 cell division
GO:0051881 regulation of mitochondrial membrane potential
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071500 cellular response to nitrosative stress
GO:1901858 regulation of mitochondrial DNA metabolic process
GO:1902882 regulation of response to oxidative stress
GO:1904031 positive regulation of cyclin-dependent protein kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR019391 Storkhead-box protein, winged-helix domainDomainDomain
IPR040126 Storkhead-box protein 1/2FamilyFamily

Diseases

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Disease IDSourceNameDescription
609404 OMIMPre-eclampsia/eclampsia 4 (PEE4)A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. The disease is caused by variants affecting the gene represented in this entry.

Interactions

7 interactions