Entity Details

Primary name MED25_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ71SY5
EntryNameMED25_HUMAN
FullNameMediator of RNA polymerase II transcription subunit 25
TaxID9606
Evidenceevidence at protein level
Length747
SequenceStatuscomplete
DateCreated2007-10-02
DateModified2021-06-02

Ontological Relatives

GenesMED25

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001223 transcription coactivator binding
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0008134 transcription factor binding
GO:0016592 mediator complex
GO:0035563 positive regulation of chromatin binding
GO:0042974 retinoic acid receptor binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0048147 negative regulation of fibroblast proliferation
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:2001178 positive regulation of mediator complex assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR021394 Mediator complex, subunit Med25, PTOV domainDomainDomain
IPR021397 Mediator complex, subunit Med25, synapsin 1DomainDomain
IPR021406 Mediator complex, subunit Med25, NR boxDomainDomain
IPR021419 Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domainDomainDomain
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR038196 Mediator complex subunit 25, PTOV domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
MED25_HUMANRARA_HUMANBioGRID, HPRD, MINT17641689 details
MED25_HUMANTHB_HUMANMINT17641689 details
MED25_HUMANRXRA_HUMANBioGRID, HPRD, MINT17641689 details
MED25_HUMANGCR_HUMANBioGRID, MINT17641689 details
MED25_HUMANABL1_HUMANMINT19290556 details
MED25_HUMANLCK_HUMANMINT19290556 details
MED25_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
MED25_HUMANTFG_HUMANBioGRID, IntAct32296183 details
MED25_HUMANESRP1_HUMANBioGRID, IntAct32296183 details
MED25_HUMANF168B_HUMANBioGRID, IntAct32296183 details
MED25_HUMANLASP1_HUMANBioGRID, IntAct32296183 details
MED25_HUMANPEF1_HUMANBioGRID, IntAct32296183 details
MED25_HUMANSPN90_HUMANBioGRID, IntAct32296183 details
MED25_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
MED25_HUMANPKHB2_HUMANBioGRID, IntAct32296183 details
MED25_HUMANSTA5B_HUMANBioGRID, IntAct32296183 details
MED25_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
MED25_HUMANUBP54_HUMANBioGRID, IntAct32296183 details
MED25_HUMANKLH12_HUMANBioGRID, IntAct32296183 details
MED25_HUMANHGS_HUMANBioGRID, IntAct32296183 details
MED25_HUMANWWP2_HUMANBioGRID, IntAct32296183 details
MED25_HUMANODAM_HUMANBioGRID, IntAct32296183 details
MED25_HUMANWWOX_HUMANBioGRID, IntAct32296183 details
MED25_HUMANEYA2_HUMANBioGRID, IntAct32296183 details
MED25_HUMANSRTD3_HUMANBioGRID, IntAct32296183 details
MED25_HUMANOXER1_HUMANBioGRID, IntAct32296183 details
MED25_HUMANRUSC1_HUMANBioGRID, IntAct32296183 details
MED25_HUMANRORB_HUMANIntAct32296183 details
MED25_HUMANESR1_HUMANBioGRID, IntAct17641689 24960263 31527615 details
MED25_HUMANSRBP1_HUMANBioGRID11834832 16799563 details
MED25_HUMANTHA_HUMANBioGRID17641689 details
MED25_HUMANCBP_HUMANBioGRID, HPRD17641689 details
MED25_HUMANCTDP1_HUMANBioGRID16239144 details
MED25_HUMANMED19_HUMANBioGRID, IntAct14576168 15175163 21729782 23563140 26186194 28514442 details
MED25_HUMANMED10_HUMANBioGRID, IntAct14576168 15175163 15989967 24882805 details
MED25_HUMANMED26_HUMANBioGRID, IntAct14657022 15175163 21729782 details
MED25_HUMANMED15_HUMANBioGRID, HPRD, IntAct14657022 14983011 24882805 details
MED25_HUMANMED14_HUMANBioGRID, IntAct14657022 24882805 25792360 details
MED25_HUMANMED16_HUMANBioGRID, IntAct14657022 24882805 25792360 details
MED25_HUMANMED24_HUMANBioGRID, IntAct24882805 25792360 26344197 details
MED25_HUMANMED23_HUMANBioGRID, IntAct, MINT14657022 24882805 25281560 25792360 26344197 details
MED25_HUMANMED12_HUMANBioGRID, IntAct14657022 20133760 26496610 details
MED25_HUMANCDK8_HUMANBioGRID, DIP, HPRD, IntAct14638676 14657022 14983011 20098423 25792360 26186194 26496610 28514442 29568061 details
MED25_HUMANMED1_HUMANBioGRID, DIP, HPRD, IntAct14657022 14983011 15989967 17641689 20098423 20133760 25792360 28514442 details
MED25_HUMANMED6_HUMANBioGRID, HPRD, IntAct14657022 14983011 17641689 25792360 details
MED25_HUMANMED28_HUMANBioGRID15175163 20133760 details
MED25_HUMANTRRAP_HUMANBioGRID18418385 details
MED25_HUMANZC3HD_HUMANBioGRID20133760 details
MED25_HUMANTRIP4_HUMANBioGRID20133760 details
MED25_HUMANSTN1_HUMANBioGRID20133760 details
MED25_HUMANQKI_HUMANBioGRID20133760 details
MED25_HUMANMED13_HUMANBioGRID14657022 29568061 details
MED25_HUMANMED25_HUMANBioGRID14657022 details
MED25_HUMANMED17_HUMANBioGRID14657022 details
MED25_HUMANMED7_HUMANBioGRID14657022 details
MED25_HUMANHCFC1_HUMANHPRD14983011 details
MED25_HUMANMED8_HUMANHPRD14638676 details