Entity Details

Primary name SFPA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IWL1
EntryNameSFPA2_HUMAN
FullNamePulmonary surfactant-associated protein A2
TaxID9606
Evidenceevidence at protein level
Length248
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesSFTPA2

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005771 multivesicular body
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0030246 carbohydrate binding
GO:0042599 lamellar body
GO:0044267 cellular protein metabolic process
GO:0045334 clathrin-coated endocytic vesicle

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001304 C-type lectin-likeDomainDomain
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR018378 C-type lectin, conserved siteSiteConserved site
IPR033990 Collectin, C-type lectin-like domainDomainDomain

Diseases

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Disease IDSourceNameDescription
178500 OMIMPulmonary fibrosis, idiopathic (IPF)A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SFPA2_HUMANNCS1_HUMANBioGRID, IntAct32296183 details
SFPA2_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details