Entity Details

Primary name FANCM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IYD8
EntryNameFANCM_HUMAN
FullNameFanconi anemia group M protein
TaxID9606
Evidenceevidence at protein level
Length2048
SequenceStatuscomplete
DateCreated2005-10-25
DateModified2021-06-02

Ontological Relatives

GenesFANCM

GO terms

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GOName
GO:0000400 four-way junction DNA binding
GO:0000712 resolution of meiotic recombination intermediates
GO:0003682 chromatin binding
GO:0003724 RNA helicase activity
GO:0004518 nuclease activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0009378 four-way junction helicase activity
GO:0031297 replication fork processing
GO:0036297 interstrand cross-link repair
GO:0043138 3'-5' DNA helicase activity
GO:0043240 Fanconi anaemia nuclear complex
GO:0045003 double-strand break repair via synthesis-dependent strand annealing
GO:0071821 FANCM-MHF complex
GO:0071932 replication fork reversal
GO:1902527 positive regulation of protein monoubiquitination

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR006166 ERCC4 domainDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR010994 RuvA domain 2-likeFamilyHomologous superfamily
IPR011335 Restriction endonuclease type II-likeFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031879 Fanconi anemia group M protein, MHF binding domainDomainDomain
IPR039686 FANCM/Mph1-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
618096 OMIMPremature ovarian failure 15 (POF15)An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. The disease is caused by variants affecting the gene represented in this entry.
618086 OMIMSpermatogenic failure 28 (SPGF28)An autosomal recessive infertility disorder caused by spermatogenesis defects that result in oligoasthenospermia or non-obstructive azoospermia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
FANCM_HUMANCENPS_HUMANBioGRID, MINT20347428 20347429 22510687 23886707 24390579 24699063 26625197 details
FANCM_HUMANTRI27_HUMANBioGRID, IntAct25416956 details
FANCM_HUMANEPN2_HUMANBioGRID, IntAct32296183 details
FANCM_HUMANFAP24_HUMANBioGRID, DIP, HPRD, IntAct17289582 18285517 18995830 20064461 20347428 20347429 23932590 23999858 24003026 24699063 28514442 details
FANCM_HUMANRMI1_HUMANBioGRID, IntAct17289582 20064461 20347428 22392978 details
FANCM_HUMANFANCF_HUMANBioGRID, IntAct16116422 17289582 20064461 20347428 24699063 24910428 details
FANCM_HUMANPCNA_HUMANBioGRID, IntAct26825464 28514442 details
FANCM_HUMANLRRK2_HUMANBioGRID, IntAct29513927 details
FANCM_HUMANCENPX_HUMANBioGRID20347428 20347429 22510687 24699063 26625197 details
FANCM_HUMANRMI2_HUMANBioGRID20064461 22392978 details
FANCM_HUMANTOP3A_HUMANBioGRID16116422 20064461 24699063 details
FANCM_HUMANEME2_HUMANBioGRID17289582 details
FANCM_HUMANA4_HUMANBioGRID21244100 21832049 details
FANCM_HUMANECT2_HUMANBioGRID22990118 details
FANCM_HUMANUBC9_HUMANBioGRID15561718 details
FANCM_HUMANFANCB_HUMANBioGRID, IntAct, MINT16116422 17289582 17396147 20347428 details
FANCM_HUMANFANCA_HUMANBioGRID, IntAct, MINT16116422 16720839 17289582 17396147 18285517 20064461 20347428 20347429 21975120 22343915 22705371 26625197 details
FANCM_HUMANFP100_HUMANBioGRID, MINT16116422 17396147 18285517 20347428 22343915 26625197 details
FANCM_HUMANEME1_HUMANIntAct17289582 details
FANCM_HUMANFANCC_HUMANBioGRID, IntAct16116422 17289582 20347428 24699063 details
FANCM_HUMANFANCE_HUMANBioGRID, IntAct16116422 16116434 17289582 18285517 20064461 20347428 24451376 24699063 details
FANCM_HUMANFANCG_HUMANBioGRID, IntAct16116422 17289582 20347428 20347429 22343915 details
FANCM_HUMANFANCL_HUMANBioGRID, IntAct16116422 16720839 17289582 17396147 18174376 18285517 20347428 20347429 22343915 24910428 27398742 details
FANCM_HUMANBLM_HUMANBioGRID, UniProt16116422 20064461 20347428 23509288 24699063 details
FANCM_HUMANFANCM_HUMANBioGRID18285517 20347429 details
FANCM_HUMANRFA1_HUMANBioGRID20347428 details
FANCM_HUMANRFA2_HUMANBioGRID20347428 details
FANCM_HUMANCLK2_HUMANBioGRID18995830 details
FANCM_HUMANFAP20_HUMANBioGRID22343915 22705371 26625197 details
FANCM_HUMANFBW1B_HUMANBioGRID19270156 22017875 details
FANCM_HUMANFBW1A_HUMANBioGRID19270156 details
FANCM_HUMANFANCI_HUMANBioGRID26625197 details
FANCM_HUMANFOXF1_HUMANBioGRID26625197 details
FANCM_HUMANTELO2_HUMANBioGRID18995830 20064461 details
FANCM_HUMANETAA1_HUMANBioGRID27723720 details