Entity Details
| Primary name |
SIX5_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q8N196 |
| EntryName | SIX5_HUMAN |
| FullName | Homeobox protein SIX5 |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 739 |
| SequenceStatus | complete |
| DateCreated | 2004-04-13 |
| DateModified | 2021-06-02 |
GO terms
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| GO | Name |
| GO:0000785 | chromatin |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0002088 | lens development in camera-type eye |
| GO:0005634 | nucleus |
| GO:0005667 | transcription regulator complex |
| GO:0005737 | cytoplasm |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0007286 | spermatid development |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:1902723 | negative regulation of skeletal muscle satellite cell proliferation |
Subcellular Location
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| Subcellular Location |
| Cytoplasm |
| Nucleus |
Domains
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| Domain | Name | Category | Type |
| IPR001356 | Homeobox domain | Domain | Domain |
| IPR009057 | Homeobox-like domain superfamily | Family | Homologous superfamily |
| IPR017970 | Homeobox, conserved site | Site | Conserved site |
| IPR031701 | Homeobox protein SIX1, N-terminal SD domain | Domain | Domain |
Diseases
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| Disease ID | Source | Name | Description |
| 610896 | OMIM | Branchiootorenal syndrome 2 (BOR2) | A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations. The disease is caused by variants affecting the gene represented in this entry. |
Interactions
3 interactions