Entity Details

Primary name TF3B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92994
EntryNameTF3B_HUMAN
FullNameTranscription factor IIIB 90 kDa subunit
TaxID9606
Evidenceevidence at protein level
Length677
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesBRF1

GO terms

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GOName
GO:0000126 transcription factor TFIIIB complex
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006352 DNA-templated transcription, initiation
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation from RNA polymerase III promoter
GO:0009303 rRNA transcription
GO:0009304 tRNA transcription
GO:0017025 TBP-class protein binding
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0046872 metal ion binding
GO:0070897 transcription preinitiation complex assembly
GO:0097550 transcription preinitiation complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000812 Transcription factor TFIIBFamilyFamily
IPR011665 Brf1, TBP-binding domainDomainDomain
IPR013137 Zinc finger, TFIIB-typeDomainDomain
IPR013150 Transcription factor TFIIB, cyclin-like domainDomainDomain
IPR013763 Cyclin-likeDomainDomain
IPR029529 Transcription factor IIIB subunit Brf1FamilyFamily
IPR036915 Cyclin-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616202 OMIMCerebellofaciodental syndrome (CFDS)An autosomal recessive disorder characterized by cerebellar hypoplasia, delayed development and intellectual disability, as well as facial dysmorphic features, short stature, microcephaly, and dental anomalies. The disease is caused by variants affecting the gene represented in this entry.