Entity Details

Primary name MEIS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14770
EntryNameMEIS2_HUMAN
FullNameHomeobox protein Meis2
TaxID9606
Evidenceevidence at protein level
Length477
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesMEIS2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001654 eye development
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007420 brain development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008542 visual learning
GO:0009612 response to mechanical stimulus
GO:0009880 embryonic pattern specification
GO:0009887 animal organ morphogenesis
GO:0031016 pancreas development
GO:0043565 sequence-specific DNA binding
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048471 perinuclear region of cytoplasm
GO:0070848 response to growth factor
GO:0110024 positive regulation of cardiac muscle myoblast proliferation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR008422 Homeobox KN domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR032453 Homeobox protein PKNOX/Meis, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
600987 OMIMCleft palate, cardiac defects, and mental retardation (CPCMR)An autosomal dominant disease characterized by multiple congenital malformations, mild-to-severe intellectual disability with poor speech, and delayed psychomotor development. Congenital malformations include heart defects, cleft lip/palate, distally-placed thumbs and toes, and cutaneous syndactyly between the second and third toes. The disease is caused by variants affecting the gene represented in this entry.

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
MEIS2_HUMANPBX1_HUMANBioGRID, IntAct, MINT11279116 20211142 20553494 26186194 28514442 32296183 details
MEIS2_HUMANPKNX1_HUMANUniProt19559479 details
MEIS2_HUMANTLX1_HUMANUniProt19559479 details
MEIS2_HUMANCA094_HUMANBioGRID, IntAct25416956 details
MEIS2_HUMANOSGI1_HUMANBioGRID, IntAct25416956 31515488 details
MEIS2_HUMANMEIS2_HUMANBioGRID, IntAct25416956 details
MEIS2_HUMANRBPMS_HUMANBioGRID, IntAct27107012 details
MEIS2_HUMANPBX4_HUMANBioGRID, IntAct26186194 28514442 32296183 details
MEIS2_HUMANNOTO_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANKR192_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANSMRP1_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANKR108_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANBPIA1_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANRUSC1_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANMS18B_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANCART_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANNDUB7_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANVGLL1_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANF136A_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANTBX2_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANANKMT_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANMCCD1_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANTRI42_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANCTG1B_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANNUP58_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANOBF1_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANKR196_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANADA2C_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANKR111_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANSECR_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANIBP6_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANT10B_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANPTK6_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANF168A_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANCENPR_HUMANBioGRID, IntAct32296183 details
MEIS2_HUMANTRI25_HUMANBioGRID, IntAct20211142 details
MEIS2_HUMANZNHI3_HUMANBioGRID, IntAct20211142 details
MEIS2_HUMANA4_HUMANBioGRID21832049 details
MEIS2_HUMANSQSTM_HUMANBioGRID14702098 details
MEIS2_HUMANARNT2_HUMANBioGRID24722188 details
MEIS2_HUMANDGCR6_HUMANBioGRID24722188 details
MEIS2_HUMANCRBN_HUMANBioGRID25043012 30458989 details
MEIS2_HUMANANXA1_HUMANBioGRID25416956 details
MEIS2_HUMANKR221_HUMANBioGRID32296183 details
MEIS2_HUMANKR131_HUMANBioGRID32296183 details
MEIS2_HUMANHXA13_HUMANHPRD15617687 details
MEIS2_HUMANSP1_HUMANBioGRID22028617 details
MEIS2_HUMANHXA9_HUMANHPRD15161102 details