Entity Details

Primary name FSCN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14926
EntryNameFSCN2_HUMAN
FullNameFascin-2
TaxID9606
Evidenceevidence at protein level
Length492
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesFSCN2

GO terms

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GOName
GO:0003779 actin binding
GO:0005737 cytoplasm
GO:0007163 establishment or maintenance of cell polarity
GO:0007601 visual perception
GO:0009653 anatomical structure morphogenesis
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0030674 protein-macromolecule adaptor activity
GO:0032420 stereocilium
GO:0042462 eye photoreceptor cell development
GO:0051015 actin filament binding
GO:0051017 actin filament bundle assembly

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR008999 Actin-crosslinkingFamilyHomologous superfamily
IPR010431 FascinFamilyFamily
IPR022768 Fascin domainDomainDomain
IPR024703 Fascin, metazoansFamilyFamily
IPR030144 Fascin-2FamilyFamily

Diseases

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Disease IDSourceNameDescription
607921 OMIMRetinitis pigmentosa 30 (RP30)A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. The disease is caused by variants affecting the gene represented in this entry.