Entity Details

Primary name HTF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99081
EntryNameHTF4_HUMAN
FullNameTranscription factor 12
TaxID9606
Evidenceevidence at protein level
Length682
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesTCF12

GO terms

Show/Hide Table
GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006955 immune response
GO:0007399 nervous system development
GO:0007517 muscle organ development
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0016607 nuclear speck
GO:0030154 cell differentiation
GO:0035497 cAMP response element binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043425 bHLH transcription factor binding
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0070888 E-box binding
GO:0071837 HMG box domain binding
GO:0090575 RNA polymerase II transcription regulator complex
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
615314 OMIMCraniosynostosis 3 (CRS3)A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability. The disease is caused by variants affecting the gene represented in this entry.

Interactions

91 interactions

InteractorPartnerSourcesPublicationsLink
HTF4_HUMANPRS23_HUMANBioGRID, HPRD, IntAct16169070 details
HTF4_HUMANTAL1_HUMANBioGRID, DIP, IntAct, MINT16407974 19497860 21179004 9824680 details
HTF4_HUMANMYF6_HUMANBioGRID, IntAct, MINT21516116 28514442 details
HTF4_HUMANHEXI2_HUMANBioGRID, IntAct, MINT21516116 25416956 28514442 32296183 details
HTF4_HUMANBMF_HUMANBioGRID, IntAct21988832 details
HTF4_HUMANLTOR5_HUMANBioGRID, IntAct23414517 details
HTF4_HUMANMABP1_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANRPC9_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANSTK16_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANPSA1_HUMANBioGRID, IntAct25416956 31515488 details
HTF4_HUMANSORCN_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANSTA5A_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANCDN2C_HUMANBioGRID, IntAct25416956 25910212 31515488 details
HTF4_HUMANSYQ_HUMANBioGRID, IntAct25416956 31515488 details
HTF4_HUMANID3_HUMANBioGRID, HPRD, IntAct20211142 25416956 31515488 32296183 9242638 details
HTF4_HUMANEDRF1_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANASCL4_HUMANBioGRID, HPRD, IntAct14516699 25416956 32296183 details
HTF4_HUMANTRI72_HUMANBioGRID, IntAct25416956 32296183 details
HTF4_HUMANARMC8_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANCF206_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANMORN4_HUMANBioGRID, IntAct25416956 32296183 details
HTF4_HUMANTWST2_HUMANBioGRID, IntAct21516116 25416956 32296183 details
HTF4_HUMANMERB1_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANLYSM1_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANTSNAX_HUMANBioGRID, IntAct25416956 32296183 details
HTF4_HUMANHOP_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANCA109_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANSPG21_HUMANBioGRID, IntAct25416956 31515488 details
HTF4_HUMANNAGK_HUMANBioGRID, IntAct25416956 details
HTF4_HUMANOSGI1_HUMANBioGRID, IntAct25416956 31515488 details
HTF4_HUMANNGN3_HUMANBioGRID, IntAct25416956 25910212 28514442 31515488 32296183 details
HTF4_HUMANID1_HUMANBioGRID, HPRD, IntAct20211142 26496610 32296183 9242638 details
HTF4_HUMANVPS28_HUMANBioGRID, IntAct25416956 26871637 details
HTF4_HUMANPIN1_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANTCF21_HUMANBioGRID, IntAct21771727 32296183 details
HTF4_HUMANARL16_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANTBC21_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANFL2D_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANHAND1_HUMANBioGRID, HPRD, IntAct11802795 32296183 details
HTF4_HUMANHAND2_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANMSGN1_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANNDF1_HUMANBioGRID, IntAct26186194 28514442 32296183 details
HTF4_HUMANTCF23_HUMANBioGRID, IntAct14516699 32296183 details
HTF4_HUMANNGN1_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANHEN2_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANNEK6_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANAAKB2_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANEXOC8_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANGRB7_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANFA50B_HUMANIntAct32296183 details
HTF4_HUMANCD20B_HUMANIntAct32296183 details
HTF4_HUMANTTF2_HUMANIntAct32296183 details
HTF4_HUMANEPHB6_HUMANIntAct32296183 details
HTF4_HUMANSH21B_HUMANIntAct32296183 details
HTF4_HUMANCCNH_HUMANIntAct32296183 details
HTF4_HUMANGTPB3_HUMANIntAct32296183 details
HTF4_HUMANCLCKA_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANMUSC_HUMANBioGRID, HPRD, IntAct32296183 9584154 details
HTF4_HUMANRBM8A_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANASCL3_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANCKS1_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANDDX6_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANFIGLA_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANNGLY1_HUMANBioGRID, IntAct32296183 details
HTF4_HUMANID2_HUMANBioGRID, DIP, HPRD, IntAct16549780 19321746 26735018 28514442 9242638 details
HTF4_HUMANFER3L_HUMANBioGRID, IntAct28514442 32296183 details
HTF4_HUMANMTG8_HUMANBioGRID, DIP, IntAct15333839 16803958 31515488 details
HTF4_HUMANNCOR1_HUMANDIP17572682 details
HTF4_HUMANTAL2_HUMANBioGRID, IntAct20211142 details
HTF4_HUMANOLIG3_HUMANBioGRID, HPRD14516699 details
HTF4_HUMANCBP_HUMANBioGRID, HPRD15333839 details
HTF4_HUMANEP300_HUMANBioGRID, HPRD11755530 15333839 30110629 details
HTF4_HUMANTAF4_HUMANBioGRID15333839 details
HTF4_HUMANTBP_HUMANBioGRID15333839 details
HTF4_HUMANDGCR6_HUMANBioGRID24722188 details
HTF4_HUMANAF17_HUMANBioGRID25416956 details
HTF4_HUMANRN5A_HUMANBioGRID25416956 details
HTF4_HUMANHTF4_HUMANBioGRID9050988 details
HTF4_HUMANFRMD6_HUMANBioGRID21516116 details
HTF4_HUMANZN688_HUMANBioGRID26871637 details
HTF4_HUMANMY15B_HUMANBioGRID32296183 details
HTF4_HUMANFOXH1_HUMANbhf-ucl, BioGRID21828274 details
HTF4_HUMANTFE2_HUMANbhf-ucl, BioGRID, HPRD12566462 1446075 21828274 details
HTF4_HUMANSMAD3_HUMANbhf-ucl, BioGRID21828274 details
HTF4_HUMANRUNX1_HUMANBioGRID15333839 details
HTF4_HUMANSMAD2_HUMANBioGRID21828274 details
HTF4_HUMANATOH1_HUMANBioGRID27542412 details
HTF4_HUMANPTF1A_HUMANHPRD10768861 1720355 details
HTF4_HUMANSOX8_HUMANHPRD16582099 details
HTF4_HUMANSOX10_HUMANHPRD16582099 details