Entity Details

Primary name LGR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BXB1
EntryNameLGR4_HUMAN
FullNameLeucine-rich repeat-containing G-protein coupled receptor 4
TaxID9606
Evidenceevidence at protein level
Length951
SequenceStatuscomplete
DateCreated2002-06-20
DateModified2021-06-02

Ontological Relatives

GenesLGR4

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0001818 negative regulation of cytokine production
GO:0001942 hair follicle development
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007283 spermatogenesis
GO:0008528 G protein-coupled peptide receptor activity
GO:0009755 hormone-mediated signaling pathway
GO:0016500 protein-hormone receptor activity
GO:0030282 bone mineralization
GO:0030539 male genitalia development
GO:0032922 circadian regulation of gene expression
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0036335 intestinal stem cell homeostasis
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046849 bone remodeling
GO:0048565 digestive tract development
GO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development
GO:0072202 cell differentiation involved in metanephros development
GO:0072224 metanephric glomerulus development
GO:0072282 metanephric nephron tubule morphogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0120163 negative regulation of cold-induced thermogenesis
GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002131 Glycoprotein hormone receptor familyFamilyFamily
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
166710 OMIMOsteoporosis (OSTEOP)A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. Disease susceptibility may be associated with variants affecting the gene represented in this entry. A LGR4 nonsense mutation creating a stop codon after position 126 (c.376C>T) is strongly associated with low bone mineral density and osteoporotic fractures (PubMed:23644456). This mutation probably causes degradation of the transcript by nonsense-mediated decay (NMD). The c.376C>T mutation is also associated with electrolyte imbalance, late onset of menarche and reduced testosterone levels, as well as an increased risk of squamous cell carcinoma of the skin and biliary tract cancer (PubMed:23644456).