Entity Details

Primary name FHR5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BXR6
EntryNameFHR5_HUMAN
FullNameComplement factor H-related protein 5
TaxID9606
Evidenceevidence at protein level
Length569
SequenceStatuscomplete
DateCreated2002-09-19
DateModified2021-06-02

Ontological Relatives

GenesCFHR5

GO terms

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GOName
GO:0005576 extracellular region
GO:0006957 complement activation, alternative pathway
GO:0030449 regulation of complement activation
GO:0032091 negative regulation of protein binding
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0051838 cytolysis by host of symbiont cells

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614809 OMIMCFHR5 deficiency (CFHR5D)A progressive disease characterized by glomerulonephritis, hematuria, renal failure, end-stage renal disease, subendothelial and mesangial glomerular C3 deposits, mesangial matrix expansion, increased glomerular cellularity, and segmental capillary wall thickening. Hematuria may become apparent after respiratory infections. The disease is caused by variants affecting the gene represented in this entry.