Entity Details

Primary name ZO2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UDY2
EntryNameZO2_HUMAN
FullNameTight junction protein ZO-2
TaxID9606
Evidenceevidence at protein level
Length1190
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesTJP2

GO terms

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GOName
GO:0004385 guanylate kinase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005923 bicellular tight junction
GO:0019904 protein domain specific binding
GO:0030674 protein-macromolecule adaptor activity
GO:0034109 homotypic cell-cell adhesion
GO:0035329 hippo signaling
GO:0035633 maintenance of blood-brain barrier
GO:0044291 cell-cell contact zone
GO:0045216 cell-cell junction organization
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0050892 intestinal absorption
GO:0090557 establishment of endothelial intestinal barrier
GO:0090559 regulation of membrane permeability
GO:0098609 cell-cell adhesion
GO:0150105 protein localization to cell-cell junction
GO:1905605 positive regulation of blood-brain barrier permeability
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR005417 Tight junction protein ZOFamilyFamily
IPR005419 Tight junction protein ZO-2FamilyFamily
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035598 ZO-2, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615878 OMIMCholestasis, progressive familial intrahepatic, 4 (PFIC4)A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. The disease is caused by variants affecting the gene represented in this entry.
607748 OMIMFamilial hypercholanemia (FHCA)A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.