| Domain | Name | Category | Type |
| IPR000380 | DNA topoisomerase, type IA | Family | Family |
| IPR003601 | DNA topoisomerase, type IA, domain 2 | Domain | Domain |
| IPR003602 | DNA topoisomerase, type IA, DNA-binding domain | Domain | Domain |
| IPR006171 | TOPRIM domain | Domain | Domain |
| IPR013497 | DNA topoisomerase, type IA, central | Domain | Domain |
| IPR013824 | DNA topoisomerase, type IA, central region, subdomain 1 | Family | Homologous superfamily |
| IPR013825 | DNA topoisomerase, type IA, central region, subdomain 2 | Family | Homologous superfamily |
| IPR013826 | DNA topoisomerase, type IA, central region, subdomain 3 | Family | Homologous superfamily |
| IPR023405 | DNA topoisomerase, type IA, core domain | Family | Homologous superfamily |
| IPR023406 | DNA topoisomerase, type IA, active site | Site | Active site |
| IPR034144 | DNA topoisomerase 3-like, TOPRIM domain | Domain | Domain |