Entity Details

Primary name FIBA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02671
EntryNameFIBA_HUMAN
FullNameFibrinogen alpha chain
TaxID9606
Evidenceevidence at protein level
Length866
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesFGA

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030198 extracellular matrix organization
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031639 plasminogen activation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034622 cellular protein-containing complex assembly
GO:0042730 fibrinolysis
GO:0043152 induction of bacterial agglutination
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045907 positive regulation of vasoconstriction
GO:0045921 positive regulation of exocytosis
GO:0046872 metal ion binding
GO:0050714 positive regulation of protein secretion
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0072377 blood coagulation, common pathway
GO:0072378 blood coagulation, fibrin clot formation
GO:0072562 blood microparticle
GO:0090277 positive regulation of peptide hormone secretion
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903561 extracellular vesicle
GO:1990000 amyloid fibril formation
GO:2000261 negative regulation of blood coagulation, common pathway
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainDomainDomain
IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domainDomainDomain
IPR020837 Fibrinogen, conserved siteSiteConserved site
IPR021996 Fibrinogen alpha C domainDomainDomain
IPR036056 Fibrinogen-like, C-terminalFamilyHomologous superfamily
IPR037579 Fibrinogen alpha chainFamilyFamily

Diseases

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Disease IDSourceNameDescription
616004 OMIMDysfibrinogenemia, congenital (DYSFIBRIN)A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). The disease is caused by variants affecting the gene represented in this entry.
105200 OMIMAmyloidosis 8 (AMYL8)A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system. The disease is caused by variants affecting the gene represented in this entry.
202400 OMIMCongenital afibrinogenemia (CAFBN)Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The disease is caused by variants affecting the gene represented in this entry. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.

Drugs

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DrugNameSourceType
DB00009 AlteplaseDrugbankbiotech
DB00015 ReteplaseDrugbankbiotech
DB00029 AnistreplaseDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB00364 SucralfateDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB04919 AlfimepraseDrugbankbiotech
DB05099 AncrodDrugbankbiotech
DB05675 EP-2104RDrugbankbiotech
DB06245 LanoteplaseDrugbankbiotech
DB11300 ThrombinDrugbankbiotech
DB11311 ProthrombinDrugbankbiotech
DB11571 Human thrombinDrugbankbiotech
DB11572 Thrombin alfaDrugbankbiotech
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
FIBA_HUMANPRC2A_HUMANBioGRID, HPRD, IntAct14667819 details
FIBA_HUMANK1C18_HUMANIntAct10954706 details
FIBA_HUMANKLK6_HUMANIntAct12878203 details
FIBA_HUMANPASK_HUMANMINT21418524 details
FIBA_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
FIBA_HUMAN3BP1_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANTMM43_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANEXOC5_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANSTX2_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANTPM3_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANTPM1_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANSTX1B_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANFA20C_HUMANIntAct22582013 26091039 details
FIBA_HUMANLAMP2_HUMANIntAct32814053 details
FIBA_HUMANSHLB1_HUMANIntAct32814053 details
FIBA_HUMANSODC_HUMANIntAct32814053 details
FIBA_HUMANTPA_HUMANBioGRID, HPRD11170397 3088041 details
FIBA_HUMANNID1_HUMANBioGRID, HPRD1680863 details
FIBA_HUMANHRG_HUMANBioGRID, HPRD9276466 details
FIBA_HUMANTSP1_HUMANBioGRID, HPRD9867861 details
FIBA_HUMANCADH5_HUMANBioGRID, HPRD11900554 details
FIBA_HUMANUBC_HUMANBioGRID23314748 details
FIBA_HUMANITA2B_HUMANBioGRID, HPRD11460491 9058485 details
FIBA_HUMANITB3_HUMANBioGRID, HPRD11460491 9058485 details
FIBA_HUMANMEOX2_HUMANBioGRID26871637 details
FIBA_HUMANATRAP_HUMANBioGRID26871637 details
FIBA_HUMANA4_HUMANBioGRID27221710 details
FIBA_HUMANSYC1L_HUMANBioGRID32296183 details
FIBA_HUMANLRP1B_HUMANBioGRID21420681 details
FIBA_HUMANHS90A_HUMANBioGRID31273033 details
FIBA_HUMANTHRB_HUMANBioGRID, HPRD, IntAct1587268 2133223 25241761 2742826 details
FIBA_HUMANF13A_HUMANBioGRID, HPRD10956659 details
FIBA_HUMANFIBA_HUMANBioGRID, HPRD9689040 details
FIBA_HUMANA2AP_HUMANHPRD10963790 14751930 details
FIBA_HUMANIPSP_HUMANHPRD8384496 8589203 details