Entity Details

Primary name RS17_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08708
EntryNameRS17_HUMAN
FullName40S ribosomal protein S17
TaxID9606
Evidenceevidence at protein level
Length135
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesRPS17

GO terms

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GOName
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002181 cytoplasmic translation
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0016020 membrane
GO:0019083 viral transcription
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0034101 erythrocyte homeostasis
GO:0042274 ribosomal small subunit biogenesis

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001210 Ribosomal protein S17eFamilyFamily
IPR018273 Ribosomal protein S17e, conserved siteSiteConserved site
IPR036401 Ribosomal protein S17e-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612527 OMIMDiamond-Blackfan anemia 4 (DBA4)A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11638 ArtenimolDrugbanksmall molecule