Entity Details

Primary name ROA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09651
EntryNameROA1_HUMAN
FullNameHeterogeneous nuclear ribonucleoprotein A1
TaxID9606
Evidenceevidence at protein level
Length372
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHNRNPA1

GO terms

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GOName
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0006405 RNA export from nucleus
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016020 membrane
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0019904 protein domain specific binding
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0035198 miRNA binding
GO:0036002 pre-mRNA binding
GO:0042149 cellular response to glucose starvation
GO:0042802 identical protein binding
GO:0051028 mRNA transport
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0061752 telomeric repeat-containing RNA binding
GO:0070062 extracellular exosome
GO:0071013 catalytic step 2 spliceosome
GO:0098505 G-rich strand telomeric DNA binding
GO:1903936 cellular response to sodium arsenite
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR021662 Nuclear factor hnRNPA1FamilyFamily
IPR034803 hnRNP A1, RNA recognition motif 2DomainDomain
IPR034845 hnRNP A1, RNA recognition motif 1DomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615424 OMIMInclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3)An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. The disease is caused by variants affecting the gene represented in this entry.
615426 OMIMAmyotrophic lateral sclerosis 20 (ALS20)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. The disease is caused by variants affecting the gene represented in this entry.

Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
ROA1_HUMANPRC2A_HUMANBioGRID, HPRD, IntAct14667819 details
ROA1_HUMANRL21_HUMANHPRD, IntAct16169070 details
ROA1_HUMANPPIL1_HUMANBioGRID, MINT22365833 details
ROA1_HUMANHNRH3_HUMANBioGRID, IntAct, MINT, UniProt22365833 22446626 22939629 25324306 26344197 26496610 34079125 details
ROA1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
ROA1_HUMANSAFB1_HUMANBioGRID, HPRD, IntAct10212141 22446626 26496610 34079125 details
ROA1_HUMANANM1_HUMANBioGRID, HPRD17264152 17643375 19101556 25324306 8288564 8663146 9891755 details
ROA1_HUMANH31T_HUMANBioGRID20850016 details
ROA1_HUMANSRPK2_HUMANBioGRID26167880 details
ROA1_HUMANCLK1_HUMANBioGRID26167880 details
ROA1_HUMANPABP2_HUMANBioGRID, HPRD12945950 details
ROA1_HUMANPHYIP_HUMANHPRD, IntAct16169070 details
ROA1_HUMANESR1_HUMANBioGRID, IntAct20348541 21182205 details
ROA1_HUMANNR0B2_HUMANBioGRID, IntAct21988832 details
ROA1_HUMANROA1_HUMANBioGRID, DIP, IntAct10772858 23455423 25009770 29439243 details
ROA1_HUMANFEN1_HUMANBioGRID, HPRD14690413 details
ROA1_HUMANFUBP2_HUMANBioGRID11003644 17643375 25324306 34079125 details
ROA1_HUMANSREK1_HUMANBioGRID, HPRD14559993 details
ROA1_HUMANOGT1_HUMANBioGRID32994395 details
ROA1_HUMANXRN1_HUMANBioGRID, HPRD, IntAct15231747 details
ROA1_HUMANTRA2B_HUMANBioGRID, MINT22365833 details
ROA1_HUMANA4_HUMANBioGRID21832049 details
ROA1_HUMANSUFU_HUMANHPRD14611647 details
ROA1_HUMANHMGA1_HUMANBioGRID, IntAct18850631 details
ROA1_HUMANTNPO1_HUMANDIP, HPRD17435768 9144189 details
ROA1_HUMANPSMD9_HUMANBioGRID, IntAct24720748 25009770 31287951 details
ROA1_HUMANKS6B2_HUMANBioGRID25324306 details
ROA1_HUMANABHGA_HUMANHPRD, IntAct14667819 details
ROA1_HUMANTFEC_HUMANBioGRID, IntAct21988832 details
ROA1_HUMANIKBA_HUMANBioGRID, HPRD11313474 details
ROA1_HUMANGCR_HUMANBioGRID15604093 details
ROA1_HUMANANM3_HUMANBioGRID19101556 details
ROA1_HUMANIKKA_HUMANBioGRID24720748 details
ROA1_HUMANUBQL2_HUMANBioGRID, UniProt25616961 details
ROA1_HUMANDNLI4_HUMANBioGRID22990118 details
ROA1_HUMANTRAF6_HUMANBioGRID28024152 details
ROA1_HUMANPTEN_HUMANBioGRID31685992 details
ROA1_HUMANERG_HUMANBioGRID24591637 details
ROA1_HUMANTSHR_HUMANBioGRID, MINT28298427 details
ROA1_HUMANU520_HUMANBioGRID22446626 25849387 details
ROA1_HUMANRNF14_HUMANBioGRID17110431 details
ROA1_HUMANANM2_HUMANBioGRID19101556 details
ROA1_HUMAN1433T_HUMANBioGRID15161933 25324306 details
ROA1_HUMANPRKDC_HUMANBioGRID14704337 details
ROA1_HUMANH31_HUMANBioGRID26912663 details
ROA1_HUMANM3K14_HUMANIntAct14743216 details
ROA1_HUMANCTNB1_HUMANBioGRID15492215 16230076 27684187 details
ROA1_HUMANCARM1_HUMANBioGRID19101556 details
ROA1_HUMANNCBP1_HUMANBioGRID, IntAct, MINT19262567 22446626 32960270 details
ROA1_HUMANHNRPC_HUMANBioGRID, IntAct, UniProt11546873 14704337 17643375 22446626 25324306 26496610 30021884 34079125 details
ROA1_HUMANNOP56_HUMANBioGRID12777385 details
ROA1_HUMANCPSF6_HUMANBioGRID22446626 34079125 details
ROA1_HUMANKHDR1_HUMANBioGRID, IntAct, MINT, UniProt17371836 20186123 24514149 26496610 34079125 details
ROA1_HUMANXIAP_HUMANBioGRID17287399 25324306 details
ROA1_HUMANSEPT6_HUMANHPIDb17229681 details
ROA1_HUMANUBQL1_HUMANUniProt25616961 details
ROA1_HUMANLARP7_HUMANBioGRID17643375 18483487 25324306 29845934 34079125 details
ROA1_HUMANSRRM2_HUMANBioGRID16159877 22939629 details
ROA1_HUMANSMN_HUMANBioGRID19928837 details
ROA1_HUMANHDAC5_HUMANBioGRID21081666 details
ROA1_HUMANPPIA_HUMANBioGRID22446626 25324306 25678563 details
ROA1_HUMANRBM45_HUMANBioGRID26979993 details
ROA1_HUMANRIPK3_HUMANIntAct14743216 details
ROA1_HUMAN1433Z_HUMANBioGRID, MINT15161933 25324306 details
ROA1_HUMANPDCD4_HUMANBioGRID25324306 details
ROA1_HUMANSF3A2_HUMANBioGRID, MINT17332742 details
ROA1_HUMANNS1BP_HUMANBioGRID23825951 details
ROA1_HUMAN1433E_HUMANBioGRID25324306 details
ROA1_HUMANGAN_HUMANBioGRID26460568 details
ROA1_HUMANU2AF2_HUMANBioGRID26641092 34079125 details
ROA1_HUMANNPM_HUMANBioGRID25349213 details
ROA1_HUMANCDC37_HUMANBioGRID16611982 details
ROA1_HUMANPAIRB_HUMANMINT24205981 details
ROA1_HUMANTOPRS_HUMANBioGRID17803295 details
ROA1_HUMANSRSF7_HUMANBioGRID15210956 details
ROA1_HUMANITA4_HUMANBioGRID22623428 details
ROA1_HUMANMAEL_HUMANBioGRID24189637 details
ROA1_HUMANNDUF8_HUMANBioGRID28162770 details
ROA1_HUMANFGF11_HUMANBioGRID28027390 details
ROA1_HUMANPSB4_HUMANBioGRID24720748 details
ROA1_HUMANZFP91_HUMANBioGRID32754263 details