Entity Details

Primary name ATTY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17735
EntryNameATTY_HUMAN
FullNameTyrosine aminotransferase
TaxID9606
Evidenceevidence at protein level
Length454
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesTAT

GO terms

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GOName
GO:0004838 L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006103 2-oxoglutarate metabolic process
GO:0006536 glutamate metabolic process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0006979 response to oxidative stress
GO:0009058 biosynthetic process
GO:0016597 amino acid binding
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0046689 response to mercury ion
GO:0051384 response to glucocorticoid

Subcellular Location

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Domains

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DomainNameCategoryType
IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding siteSiteBinding site
IPR004839 Aminotransferase, class I/classIIDomainDomain
IPR005957 Tyrosine aminotransferaseFamilyFamily
IPR005958 Tyrosine/nicotianamine aminotransferaseFamilyFamily
IPR011715 Tyrosine aminotransferase ubiquitination regionDomainDomain
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
276600 OMIMTyrosinemia 2 (TYRSN2)An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00120 PhenylalanineDrugbanksmall molecule
DB00135 TyrosineDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule