Entity Details

Primary name ATF6A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18850
EntryNameATF6A_HUMAN
FullNameCyclic AMP-dependent transcription factor ATF-6 alpha
TaxID9606
Evidenceevidence at protein level
Length670
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesATF6

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001654 eye development
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006457 protein folding
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0010508 positive regulation of autophagy
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0035497 cAMP response element binding
GO:0036500 ATF6-mediated unfolded protein response
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:1903893 positive regulation of ATF6-mediated unfolded protein response
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
Nucleus

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain
IPR029801 cAMP-dependent transcription factor ATF-6 alphaFamilyFamily

Diseases

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Disease IDSourceNameDescription
616517 OMIMAchromatopsia 7 (ACHM7)A form of achromatopsia, an ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00852 PseudoephedrineDrugbanksmall molecule