Entity Details

Primary name FGFR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22455
EntryNameFGFR4_HUMAN
FullNameFibroblast growth factor receptor 4
TaxID9606
Evidenceevidence at protein level
Length802
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesFGFR4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010715 regulation of extracellular matrix disassembly
GO:0016477 cell migration
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019216 regulation of lipid metabolic process
GO:0030133 transport vesicle
GO:0033674 positive regulation of kinase activity
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0043085 positive regulation of catalytic activity
GO:0043235 receptor complex
GO:0045862 positive regulation of proteolysis
GO:0046777 protein autophosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0055062 phosphate ion homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070857 regulation of bile acid biosynthetic process
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum
Endosome
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
176807 OMIMProstate cancer (PC)A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. The gene represented in this entry is involved in disease pathogenesis. FGFR4 variant Arg-388 has been associated with prostate cancer as well as cancers of the breast, colon, head and neck, larynx, lung, skin. Arg-388 predisposes cancer patients for accelerated disease progression and is associated with poor prognosis.

Drugs

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DrugNameSourceType
DB01109 HeparinDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule

Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
FGFR4_HUMANFGF1_HUMANBioGRID, HPRD, IntAct10336501 10736564 11714710 1709094 25241761 details
FGFR4_HUMANANGL4_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANBLID_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANCASC3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANESIP1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANERRFI_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANGLCE_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANLRAT2_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANOSGI1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANMTA3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANPDLI2_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANHOP2_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANRSLAB_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANBRE1A_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANSG3A1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANNSD3_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANWIF1_HUMANBioGRID, MINT25640309 details
FGFR4_HUMANFGF19_HUMANBioGRID, DIP, HPRD10525310 19706524 details
FGFR4_HUMANPP2BA_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTN12_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTN6_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTN11_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
FGFR4_HUMANFGFR4_HUMANBioGRID, HPRD10918587 28205554 8576110 details
FGFR4_HUMANERBB2_HUMANBioGRID28205554 30898150 details
FGFR4_HUMANABCB5_HUMANBioGRID28205554 details
FGFR4_HUMANARNT_HUMANBioGRID28205554 details
FGFR4_HUMANBECN1_HUMANBioGRID28205554 details
FGFR4_HUMANCCND2_HUMANBioGRID28205554 details
FGFR4_HUMANCD44_HUMANBioGRID28205554 details
FGFR4_HUMANCDK4_HUMANBioGRID28205554 details
FGFR4_HUMANCDK6_HUMANBioGRID28205554 details
FGFR4_HUMANCDN2C_HUMANBioGRID28205554 details
FGFR4_HUMANAKT1_HUMANBioGRID28205554 details
FGFR4_HUMANCDN2B_HUMANBioGRID28205554 details
FGFR4_HUMANEPHA2_HUMANBioGRID28205554 details
FGFR4_HUMANMP2K3_HUMANBioGRID28205554 28628118 details
FGFR4_HUMANFZR1_HUMANBioGRID28205554 details
FGFR4_HUMANGLIS2_HUMANBioGRID28205554 details
FGFR4_HUMANGRM1_HUMANBioGRID28205554 details
FGFR4_HUMANERD22_HUMANBioGRID28205554 details
FGFR4_HUMANLATS2_HUMANBioGRID28205554 details
FGFR4_HUMANMP2K5_HUMANBioGRID28205554 details
FGFR4_HUMANMET_HUMANBioGRID28205554 details
FGFR4_HUMANMYC_HUMANBioGRID28205554 details
FGFR4_HUMANMERL_HUMANBioGRID28205554 details
FGFR4_HUMANPGFRA_HUMANBioGRID28205554 details
FGFR4_HUMANRAF1_HUMANBioGRID28205554 details
FGFR4_HUMANRASF1_HUMANBioGRID28205554 details
FGFR4_HUMANSTK11_HUMANBioGRID28205554 details
FGFR4_HUMANTTYH2_HUMANBioGRID28205554 details
FGFR4_HUMANARAF_HUMANBioGRID28205554 details
FGFR4_HUMANCBLC_HUMANBioGRID28205554 details
FGFR4_HUMANCDN2A_HUMANBioGRID28205554 details
FGFR4_HUMANARF_HUMANBioGRID28205554 details
FGFR4_HUMANCCNE1_HUMANBioGRID28205554 details
FGFR4_HUMANHGF_HUMANBioGRID28205554 details
FGFR4_HUMANHIF1A_HUMANBioGRID28205554 details
FGFR4_HUMANIGF1R_HUMANBioGRID28205554 details
FGFR4_HUMANMP2K6_HUMANBioGRID28205554 details
FGFR4_HUMANM3K5_HUMANBioGRID28205554 details
FGFR4_HUMANMK14_HUMANBioGRID28205554 details
FGFR4_HUMANMDM4_HUMANBioGRID28205554 details
FGFR4_HUMANMSH2_HUMANBioGRID28205554 details
FGFR4_HUMANROS1_HUMANBioGRID28205554 details
FGFR4_HUMANTEAD2_HUMANBioGRID28205554 details
FGFR4_HUMANTERT_HUMANBioGRID28205554 details
FGFR4_HUMANP53_HUMANBioGRID28205554 details
FGFR4_HUMANTSC1_HUMANBioGRID28205554 details
FGFR4_HUMANFGF5_HUMANBioGRID, HPRD, IntAct25241761 8663044 details
FGFR4_HUMANMMP14_HUMANDIP20798051 details
FGFR4_HUMANEPHA4_HUMANBioGRID, HPRD16365308 details
FGFR4_HUMANKLOTB_HUMANBioGRID17623664 details
FGFR4_HUMANCADH2_HUMANHPRD9168198 details
FGFR4_HUMANSTAT3_HUMANHPRD10918587 11294897 11350938 11940572 12244095 12576423 12626508 14551213 8626374 details
FGFR4_HUMANFGF7_HUMANHPRD7680645 details
FGFR4_HUMANFGF3_HUMANHPRD8663044 details
FGFR4_HUMANFGF4_HUMANHPRD8663044 details
FGFR4_HUMANPLCG1_HUMANHPRD7518429 details
FGFR4_HUMANFGF9_HUMANHPRD8663044 details
FGFR4_HUMANFGF17_HUMANHPRD10751172 details
FGFR4_HUMANFGF2_HUMANHPRD8530375 details
FGFR4_HUMANFGF6_HUMANHPRD1385111 details
FGFR4_HUMANFGF8_HUMANHPRD10736564 details
FGFR4_HUMANSTAT1_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details