Entity Details

Primary name PPIB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23284
EntryNamePPIB_HUMAN
FullNamePeptidyl-prolyl cis-trans isomerase B
TaxID9606
Evidenceevidence at protein level
Length216
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesPPIB

GO terms

Show/Hide Table
GOName
GO:0000413 protein peptidyl-prolyl isomerization
GO:0003723 RNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005925 focal adhesion
GO:0006457 protein folding
GO:0016018 cyclosporin A binding
GO:0016020 membrane
GO:0030199 collagen fibril organization
GO:0030593 neutrophil chemotaxis
GO:0032991 protein-containing complex
GO:0040018 positive regulation of multicellular organism growth
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0044794 positive regulation by host of viral process
GO:0044829 positive regulation by host of viral genome replication
GO:0048471 perinuclear region of cytoplasm
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0060348 bone development
GO:0061077 chaperone-mediated protein folding
GO:0070062 extracellular exosome
GO:0070063 RNA polymerase binding

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum lumen
Melanosome
Virion

Domains

Show/Hide Table
DomainNameCategoryType
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainDomainDomain
IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved siteSiteConserved site
IPR029000 Cyclophilin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
259440 OMIMOsteogenesis imperfecta 9 (OI9)A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00172 ProlineDrugbanksmall molecule
DB04447 1,4-DithiothreitolDrugbanksmall molecule

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
PPIB_HUMANDYN2_HUMANHPRD, IntAct16169070 details
PPIB_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
PPIB_HUMANSGTB_HUMANBioGRID, IntAct, MINT21516116 32296183 details
PPIB_HUMANAT12A_HUMANBioGRID, IntAct21988832 details
PPIB_HUMANZYX_HUMANmbinfo11423549 details
PPIB_HUMANENPL_HUMANBioGRID, IntAct22665516 24981860 details
PPIB_HUMANPDIA4_HUMANBioGRID, IntAct22665516 24981860 30021884 34079125 details
PPIB_HUMANSGTA_HUMANBioGRID, IntAct25416956 32296183 details
PPIB_HUMANPEX19_HUMANBioGRID, IntAct25416956 32296183 details
PPIB_HUMANBANP_HUMANBioGRID, IntAct25416956 details
PPIB_HUMANUBQL1_HUMANBioGRID, IntAct25416956 details
PPIB_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details
PPIB_HUMANHSP76_HUMANBioGRID, IntAct32296183 details
PPIB_HUMANTRDN_HUMANBioGRID, IntAct32296183 details
PPIB_HUMANCENPV_HUMANIntAct32814053 details
PPIB_HUMANKCD17_HUMANIntAct32814053 details
PPIB_HUMANLHX5_HUMANIntAct32814053 details
PPIB_HUMANGPT2L_HUMANIntAct32814053 details
PPIB_HUMANRMND1_HUMANIntAct32814053 details
PPIB_HUMANWWOX_HUMANBioGRID, IntAct24550385 32814053 details
PPIB_HUMANKLF12_HUMANIntAct32814053 details
PPIB_HUMANGPAA1_HUMANIntAct32814053 details
PPIB_HUMANSTIM1_HUMANIntAct32814053 details
PPIB_HUMANID2_HUMANIntAct32814053 details
PPIB_HUMANHXC4_HUMANIntAct32814053 details
PPIB_HUMANGABP1_HUMANIntAct32814053 details
PPIB_HUMANCAMLG_HUMANBioGRID7522304 details
PPIB_HUMANPRL_HUMANBioGRID, HPRD10935542 details
PPIB_HUMANVKOR1_HUMANBioGRID21103663 details
PPIB_HUMANH31T_HUMANBioGRID20850016 details
PPIB_HUMANESR1_HUMANBioGRID20348541 details
PPIB_HUMANMDM2_HUMANBioGRID24583282 29876924 details
PPIB_HUMANGLP1R_HUMANBioGRID28597972 details
PPIB_HUMANP53_HUMANBioGRID29876924 details
PPIB_HUMANPRPC_HUMANBioGRID32296183 details
PPIB_HUMANTRAF1_HUMANIntAct14743216 details
PPIB_HUMANPINX1_HUMANIntAct17353931 details
PPIB_HUMANTRM7_HUMANIntAct17353931 details
PPIB_HUMANCRCM_HUMANIntAct17353931 details
PPIB_HUMANIKKE_HUMANIntAct17353931 details
PPIB_HUMANHLAB_HUMANIntAct17353931 details
PPIB_HUMANTRAF6_HUMANIntAct17353931 details
PPIB_HUMANF86JP_HUMANIntAct30021884 details
PPIB_HUMANGAG2E_HUMANIntAct30021884 details
PPIB_HUMANAPOB_HUMANBioGRID, HPRD12397072 details
PPIB_HUMANPCM1_HUMANBioGRID21956701 details
PPIB_HUMANOS9_HUMANBioGRID23097496 details
PPIB_HUMANDDIT3_HUMANBioGRID24270407 details
PPIB_HUMANU2AF2_HUMANBioGRID26641092 details
PPIB_HUMANIRF3_HUMANHPRD15764595 details
PPIB_HUMANSTA5A_HUMANHPRD11997457 details