Entity Details

Primary name EDNRA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25101
EntryNameEDNRA_HUMAN
FullNameEndothelin-1 receptor
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesEDNRA

GO terms

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GOName
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004962 endothelin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007507 heart development
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0008217 regulation of blood pressure
GO:0008283 cell population proliferation
GO:0010827 regulation of glucose transmembrane transport
GO:0014032 neural crest cell development
GO:0014824 artery smooth muscle contraction
GO:0042310 vasoconstriction
GO:0048484 enteric nervous system development
GO:0060322 head development

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000499 Endothelin receptor familyFamilyFamily
IPR002175 Endothelin receptor AFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Disease IDSourceNameDescription
616367 OMIMMandibulofacial dysostosis with alopecia (MFDA)A form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00559 BosentanDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACIDDrugbanksmall molecule
DB04883 DarusentanDrugbanksmall molecule
DB05290 SPP 301Drugbanksmall molecule
DB05367 Actelion-1Drugbanksmall molecule
DB06199 AtrasentanDrugbanksmall molecule
DB06268 SitaxentanDrugbanksmall molecule
DB06403 AmbrisentanDrugbanksmall molecule
DB06460 EnrasentanDrugbanksmall molecule
DB06558 TezosentanDrugbanksmall molecule
DB06677 ClazosentanDrugbanksmall molecule
DB08932 MacitentanDrugbanksmall molecule
DB12548 SparsentanDrugbanksmall molecule