Entity Details

Primary name LYOX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28300
EntryNameLYOX_HUMAN
FullNameProtein-lysine 6-oxidase
TaxID9606
Evidenceevidence at protein level
Length417
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesLOX

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0001932 regulation of protein phosphorylation
GO:0004720 protein-lysine 6-oxidase activity
GO:0005507 copper ion binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0006464 cellular protein modification process
GO:0007507 heart development
GO:0010468 regulation of gene expression
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0018057 peptidyl-lysine oxidation
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030282 bone mineralization
GO:0030324 lung development
GO:0031012 extracellular matrix
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035905 ascending aorta development
GO:0035906 descending aorta development
GO:0042060 wound healing
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043491 protein kinase B signaling
GO:0045652 regulation of megakaryocyte differentiation
GO:0046716 muscle cell cellular homeostasis
GO:0048251 elastic fiber assembly
GO:0048514 blood vessel morphogenesis
GO:0048545 response to steroid hormone
GO:0060326 cell chemotaxis
GO:0061448 connective tissue development
GO:0071897 DNA biosynthetic process
GO:1900120 regulation of receptor binding
GO:1903010 regulation of bone development
GO:1990869 cellular response to chemokine
GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001695 Lysyl oxidaseFamilyFamily
IPR019828 Lysyl oxidase, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
617168 OMIMAortic aneurysm, familial thoracic 10 (AAT10)A form of thoracic aortic aneurysm, a disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB06778 Cupric sulfateSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
LYOX_HUMANFBLN4_HUMANDIP, matrixdb19570982 19855011 details
LYOX_HUMANELN_HUMANBioGRID, HPRD, matrixdb12686141 19570982 6912069 details
LYOX_HUMANFBN1_HUMANmatrixdb19570982 details
LYOX_HUMANFBLN5_HUMANmatrixdb19570982 25118846 details
LYOX_HUMANCO1A1_HUMANmatrixdb21690299 details
LYOX_HUMANCO1A2_HUMANmatrixdb21690299 details
LYOX_HUMANCO3A1_HUMANmatrixdb21690299 details
LYOX_HUMANFINC_HUMANmatrixdb21690299 details
LYOX_HUMANPTPRK_HUMANBioGRID, matrixdb21690299 details
LYOX_HUMANAP2C_HUMANIntAct24835590 details
LYOX_HUMANP66B_HUMANmatrixdb25118846 details
LYOX_HUMANMEMO1_HUMANmatrixdb25118846 details
LYOX_HUMANMDC1_HUMANmatrixdb25118846 details
LYOX_HUMANSOS2_HUMANmatrixdb25118846 details
LYOX_HUMANPA2G4_HUMANmatrixdb25118846 details
LYOX_HUMANUXT_HUMANmatrixdb28106301 details
LYOX_HUMANATL4_HUMANmatrixdb29758265 details
LYOX_HUMANDHDDS_HUMANBioGRID, HPRD15110773 details
LYOX_HUMANH11_HUMANBioGRID12686141 details
LYOX_HUMANH2B2E_HUMANBioGRID12686141 details
LYOX_HUMANRAF1_HUMANBioGRID22438909 details
LYOX_HUMANLYOX_HUMANHPRD15110773 details
LYOX_HUMANHS71A_HUMANmatrixdb21536655 details
LYOX_HUMANHS71B_HUMANmatrixdb21536655 details
LYOX_HUMANATP7A_HUMANmatrixdb31932435 details
LYOX_HUMANATOX1_HUMANmatrixdb31932435 details
LYOX_HUMANSH3K1_HUMANBioGRID24167568 details
LYOX_HUMANCD2AP_HUMANBioGRID24167568 details
LYOX_HUMANCBL_HUMANBioGRID24167568 details
LYOX_HUMANDERM_HUMANHPRD8082810 details
LYOX_HUMANH15_HUMANHPRD12686141 details
LYOX_HUMANH2B1J_HUMANHPRD12686141 details