Entity Details

Primary name FCG2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31994
EntryNameFCG2B_HUMAN
FullNameLow affinity immunoglobulin gamma Fc region receptor II-b
TaxID9606
Evidenceevidence at protein level
Length310
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesFCGR2B

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001811 negative regulation of type I hypersensitivity
GO:0001814 negative regulation of antibody-dependent cellular cytotoxicity
GO:0001818 negative regulation of cytokine production
GO:0002266 follicular dendritic cell activation
GO:0002313 mature B cell differentiation involved in immune response
GO:0002316 follicular B cell differentiation
GO:0002436 immune complex clearance by monocytes and macrophages
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0002622 regulation of B cell antigen processing and presentation
GO:0002638 negative regulation of immunoglobulin production
GO:0002819 regulation of adaptive immune response
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0002922 positive regulation of humoral immune response
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004888 transmembrane signaling receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0009617 response to bacterium
GO:0009897 external side of plasma membrane
GO:0010469 regulation of signaling receptor activity
GO:0016032 viral process
GO:0016064 immunoglobulin mediated immune response
GO:0019772 low-affinity IgG receptor activity
GO:0019864 IgG binding
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0021549 cerebellum development
GO:0030889 negative regulation of B cell proliferation
GO:0032693 negative regulation of interleukin-10 production
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043031 negative regulation of macrophage activation
GO:0043197 dendritic spine
GO:0043318 negative regulation of cytotoxic T cell degranulation
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050765 negative regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050776 regulation of immune response
GO:0050777 negative regulation of immune response
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0050869 negative regulation of B cell activation
GO:0071219 cellular response to molecule of bacterial origin
GO:0090264 regulation of immune complex clearance by monocytes and macrophages
GO:1901216 positive regulation of neuron death
GO:1902564 negative regulation of neutrophil activation
GO:1902950 regulation of dendritic spine maintenance
GO:1904646 cellular response to amyloid-beta
GO:1905898 positive regulation of response to endoplasmic reticulum stress
GO:2001199 negative regulation of dendritic cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
152700 OMIMSystemic lupus erythematosus (SLE)A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00005 EtanerceptDrugbankbiotech
DB00028 Human immunoglobulin GDrugbankbiotech
DB00054 AbciximabDrugbankbiotech
DB00081 TositumomabDrugbankbiotech
DB00087 AlemtuzumabDrugbankbiotech
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB00110 PalivizumabDrugbankbiotech
DB00111 DaclizumabDrugbankbiotech
DB00112 BevacizumabDrugbankbiotech
DB11767 SarilumabDrugbankbiotech